Encapsulation of gadolinium ferrite nanoparticle in generation 4.5 poly(amidoamine) dendrimer for cancer theranostics applications using low frequency alternating magnetic field

被引：35

作者：

Mekonnen, Tefera Worku ^{[1
]}

Birhan, Yihenew Simegniew ^{[1
]}

Andrgie, Abegaz Tizazu ^{[1
]}

Hanurry, Endiries Yibru ^{[1
]}

Darge, Haile Fentahun ^{[1
]}

Chou, Hsiao-Ying ^{[1
]}

Lai, Juin-Yih ^{[1
,2
,3
]}

Tsai, Hsieh-Chih ^{[1
,2
]}

Yang, Jen Ming ^{[4
,5
]}

Chang, Yen-Hsiang ^{[5
]}

机构：

[1] Natl Taiwan Univ Sci & Technol, Grad Inst Appl Sci & Technol, Taipei 106, Taiwan

[2] Natl Taiwan Univ Sci & Technol, Adv Membrane Mat Ctr, Taipei 106, Taiwan

[3] Chung Yuan Christian Univ, R&D Ctr Membrane Technol, Taoyuan 320, Taiwan

[4] Chang Gung Univ, Dept Chem & Mat Engn, Taoyuan 333, Taiwan

[5] Chang Gung Mem Hosp, Dept Gen Dent, Taoyuan 333, Taiwan

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2019年 / 184卷

关键词：

Cancer; Encapsulation; Gadolinium ferrite; Poly(amidoamine); Magnetic field; Theranostics; IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; IN-VITRO; POLYAMIDOAMINE DENDRIMER; CELLULAR UPTAKE; GD; DOXORUBICIN; RELEASE; MRI; AGENTS;

D O I：

10.1016/j.colsurfb.2019.110531

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Iron oxide-based magnetic resonance imaging (MRI) contrast agents have negative contrast limitations in cancer diagnosis. Gadolinium (Gd)-based contrast agents show toxicity. To overcome these limitations, Gd-doped ferrite (Gd:Fe3O4 (GdIO) nanoparticles (NPs) were synthesized as T1-T2 dual-modal contrast agents for MRI-traced drug delivery. A theranostics GdIO encapsulated in a Generation 4.5 PAMAM dendrimer (G4.5-GdIO) was developed by alkaline coprecipitation. The drug-loading efficiency of the NPs was similar to 24%. In the presence of a low-frequency alternating magnetic field (LFAMF), a maximum cumulative doxorubicin (DOX) release of similar to 77.47% was achieved in a mildly acidic (pH = 5.0) simulated endosomal microenvironment. Relaxometric measurements indicated superior r1 (5.19 mM(-1)s(-1)) and r2 (26.13 mM(-1)s(-1)) for G4.5-GdIO relative to commercially available Gd-DTPA. Thus, G4.5-GdIO is promising as an alternative noninvasive MRI-traced cancer drug delivery system.

引用

页数：9

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