Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease

被引：123
作者：
Cabral, GA [1 ]
Pettit, DAD
机构：
[1] Virginia Commonwealth Univ, Med Coll Virginia, Dept Microbiol & Immunol, Richmond, VA 23298 USA
[2] Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 1998年 / 83卷 / 1-2期
关键词：
cannabinoids; delta-9-tetrahydrocannabinol; drugs and immunity; herpes simplex virus; marijuana;
D O I：
10.1016/S0165-5728(97)00227-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Marijuana, Cannabis sativa, elicits a variety of effects in experimental animals and humans. Delta-9-tetrahydrocannabinol (THC) is the major psychoactive component in marijuana. This substance has been shown, also, to be immunosuppressive and to decrease host resistance to bacterial, protozoan, and viral infections. Macrophages, T lymphocytes, and natural killer cells appear to be major targets of the immunosuppressive effects of THC. Definitive data which directly link marijuana use to increased susceptibility to infection in humans currently is unavailable. However, cumulative reports indicating that THC alters resistance to infection in vitro and in a variety of experimental animals support the hypothesis that a similar effect occurs in humans. (C) 1998 Elsevier Science B.V.
引用
收藏
页码：116 / 123
页数：8
相关论文
共 57 条
  • [1] ARATA S, 1992, P SOC EXP BIOL MED, V199, P65
  • [2] EFFECTS OF DELTA-9-TETRAHYDROCANNABINOL, CANNABINOL AND CANNABIDIOL ON THE IMMUNE-SYSTEM IN MICE .1. INVIVO INVESTIGATION OF THE PRIMARY AND SECONDARY IMMUNE-RESPONSE
    BACZYNSKY, WOT
    ZIMMERMAN, AM
    [J]. PHARMACOLOGY, 1983, 26 (01) : 1 - 11
  • [3] DELTA-9-TETRAHYDROCANNABINOL INHIBITS CELL CONTACT-DEPENDENT CYTOTOXICITY OF BACILLUS CALMETTE-GUERIN-ACTIVATED MACROPHAGES
    BURNETTECURLEY, D
    MARCIANOCABRAL, F
    FISCHERSTENGER, K
    CABRAL, GA
    [J]. INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1993, 15 (03): : 371 - &
  • [4] CABRAL GA, 1991, ADV EXP MED BIOL, V288, P93
  • [5] CABRAL GA, 1991, ADV BIOSCI, V80, P93
  • [6] CABRAL GA, 1986, P SOC EXP BIOL MED, V182, P181
  • [7] CABRAL GA, 1986, P SOC EXP BIOL MED, V181, P305
  • [8] CABRAL GA, 1992, CANNABIS PHYSIOPATHO, P137
  • [9] CONTROLLED CYCLE OF TETRAHYDROCANNABINOL SMOKING - T AND B CELL ROSETTE FORMATION
    CUSHMAN, P
    KHURANA, R
    [J]. LIFE SCIENCES, 1977, 20 (06) : 971 - 979
  • [10] CUSHMAN P, 1976, CLIN PHARMACOL THER, V19, P310
123456