Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease

被引：123
作者：
Cabral, GA [1 ]
Pettit, DAD
机构：
[1] Virginia Commonwealth Univ, Med Coll Virginia, Dept Microbiol & Immunol, Richmond, VA 23298 USA
[2] Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 1998年 / 83卷 / 1-2期
关键词：
cannabinoids; delta-9-tetrahydrocannabinol; drugs and immunity; herpes simplex virus; marijuana;
D O I：
10.1016/S0165-5728(97)00227-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Marijuana, Cannabis sativa, elicits a variety of effects in experimental animals and humans. Delta-9-tetrahydrocannabinol (THC) is the major psychoactive component in marijuana. This substance has been shown, also, to be immunosuppressive and to decrease host resistance to bacterial, protozoan, and viral infections. Macrophages, T lymphocytes, and natural killer cells appear to be major targets of the immunosuppressive effects of THC. Definitive data which directly link marijuana use to increased susceptibility to infection in humans currently is unavailable. However, cumulative reports indicating that THC alters resistance to infection in vitro and in a variety of experimental animals support the hypothesis that a similar effect occurs in humans. (C) 1998 Elsevier Science B.V.
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收藏
页码：116 / 123
页数：8
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