Dopaminergic and other genes related to reward induced overeating, Bulimia, Anorexia Nervosa, and Binge eating

被引：0

作者：

Blum, Kenneth ^{[1
,2
,3
,4
,5
,6
,7
]}

Thanos, Panayotis K. ^{[8
]}

Wang, Gene Jack ^{[9
]}

Bowirrat, Abdalla ^{[10
,11
]}

Gomez, Luis Llanos ^{[2
]}

Baron, David ^{[1
]}

Jalali, Rehan ^{[2
]}

Gondre-Lewis, Marjorie C. ^{[12
]}

Gold, Mark S. ^{[13
]}

机构：

[1] Western Univ Hlth Sci, Ctr Psychiat Med & Primary Care Off Provost, Div Addict Res & Educ, Grad Sch Biomed Sci, Pomona, CA USA

[2] Div Ivitalize Inc, Dept Precis Behav Management, Kenneth Blum Behav Neurogenet Inst, Austin, TX 78701 USA

[3] Eotvos Lorand Univ, Inst Psychol, Budapest, Hungary

[4] Univ Vermont, Dept Psychiat, Burlington, VT USA

[5] Inst Integrat Omics & Appl Biotechnol, Ctr Genom & Appl Gene Technol, Nonakuri, India

[6] Wright State Univ, Dept Psychiat, Boonshoft Sch Med, Dayton, OH USA

[7] Dayton Va Med Ctr, Dayton, OH USA

[8] Univ Buffalo, Res Inst Addict, Behav Neuropharmacol & Neuroimaging Lab Addict, Buffalo, NY USA

[9] NIAAA, Lab Neuroimaging, Bethesda, MD USA

[10] Ariel Univ, Dept Mol Biol, Ariel, Israel

[11] Ariel Univ, Adelson Sch Med, Ariel, Israel

[12] Howard Univ, Coll Med, Neuropsychopharmacol Lab, Dept Anat, Washington, DC USA

[13] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

来源：

EXPERT REVIEW OF PRECISION MEDICINE AND DRUG DEVELOPMENT | 2022年 / 7卷 / 01期

关键词：

Eating disorders; overeating; binging; Bulimia Nervosa; undereating; Anorexia Nervosa; neurogenetics; Genetic Addiction Risk Severity (GARS); dopamine homeostasis; polymorphic genetic antecedents; hypodopaminergia; COMT VAL158MET POLYMORPHISM; GENOME-WIDE ASSOCIATION; D2 RECEPTOR GENE; FOOD ADDICTION; MESOLIMBIC DOPAMINE; NUCLEUS-ACCUMBENS; SUGAR ADDICTION; BRAIN DOPAMINE; MESSENGER-RNA; WEIGHT-GAIN;

D O I：

10.1080/23808993.2021.1994186

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Introduction: Eating Disorders and Obesity are a primary global public health concern. Areas Covered: This article aims to trace the neurochemical mechanisms of unwanted eating disorders and target specific loci, within the Brain Reward Cascade (BRC) for therapeutic interventions. Changes due to BRC polymorphisms in functional connectivity and neurotransmission can manifest as overeating, Bulimia Nervosa, and Anorexia Nervosa, and other related eating disorders. Expert opinion: Variations in dopamine function within the Ventral Tegmental Area (VTA), Nucleus Accumbens (NAc), and Ventral Striatum of individuals result in different outcomes related to maladaptive eating behaviors. The goal is to reduce maladaptive eating behaviors by implementing novel strategies that induce Dopamine Homeostasis within the BRC. Clinicians determine genetic risk severity and identify polymorphic targets for either pharmaceutical or nutraceutical interventions. Precision neuro-nutrient formulations of KB220 (Research ID Code) matched precisely to deficient neurotransmitter systems may promote the long-term development of 'dopamine homeostasis' to treat and prevent overeating, Bulimia, and Anorexia Nervosa.

引用

页码：79 / 95

页数：17

共 139 条

[11] BLUM K, 1995, FUNCT NEUROL, V10, P37
[12] Blum K., 2011, J. Genet. Syndr. Gene Ther, V2012, pS2, DOI [10.4172/2157-7412.S2-001, DOI 10.4172/2157-7412.S2-001, 10.4172/2157-7412.S2-001.S2-001, DOI 10.4172/2157-7412.S2-001.S2-001]
[13] Blum K., 1990, Alcohol and Behavior, P131
[14] Reward deficiency syndrome in obesity: A preliminary cross-sectional trial with a genotrim variant
Blum, Kenneth
Chen, Thomas J. H.
Meshkin, Brian
Downs, B. William
Gordon, Cory A.
Blum, Seth
Mengucci, Julie F.
Braverman, Eric R.
Arcuri, Vanessa
Varshavskiy, Michael
Deutsch, Roger
Martinez-Pons, Manuel
[J]. ADVANCES IN THERAPY, 2006, 23 (06) : 1040 - 1051
[15] Blum Kenneth, 2020, Curr Psychopharmacol, V9, P7
[16] Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors
Blum, Kenneth
Gondre-Lewis, Marjorie C.
Baron, David
Thanos, Panayotis K.
Braverman, Eric R.
Neary, Jennifer
Elman, Igor
Badgaiyan, Rajendra D.
[J]. FRONTIERS IN PSYCHIATRY, 2018, 9 : 1 - 14
[17] The Food and Drug Addiction Epidemic: Targeting Dopamine Homeostasis
Blum, Kenneth
Thanos, Panayotis K.
Wang, Gene-Jack
Febo, Marcelo
Demetrovics, Zsolt
Modestino, Edward Justin
Braverman, Eric R.
Baron, David
Badgaiyan, Rajendra D.
Gold, Mark S.
[J]. CURRENT PHARMACEUTICAL DESIGN, 2017, 23 (39) : 6050 - 6061
[18] Blum Kenneth, 2015, J Reward Defic Syndr, V1, P75
[19] Dopamine and glucose, obesity, and reward deficiency syndrome
Blum, Kenneth
Thanos, Panayotis K.
Gold, Mark S.
[J]. FRONTIERS IN PSYCHOLOGY, 2014, 5
[20] Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary
Blum, Kenneth
Chen, Amanda Lih Chuan
Chen, Thomas J. H.
Braverman, Eric R.
Reinking, Jeffrey
Blum, Seth H.
Cassel, Kimberly
Downs, Bernard W.
Waite, Roger L.
Williams, Lonna
Prihoda, Thomas J.
Kerner, Mallory M.
Palomo, Tomas
Comings, David E.
Tung, Howard
Rhoades, Patrick
Oscar-Berman, Marlene
[J]. THEORETICAL BIOLOGY AND MEDICAL MODELLING, 2008, 5

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