Microwave assisted benzylation of naphthols and 4-hydroxycoumarin under catalyst & solvent free conditions

被引：20
作者：
Dada, Ravikrishna [1 ]
Singh, Garima [1 ]
Pareek, Abhishek [1 ]
Kausar, Saeen [1 ]
Yaragorla, Srinivasarao [1 ]
机构：
[1] Cent Univ Rajasthan, Dept Chem, SY Organ & Med Chem Lab, Bandarsindri NH-8, Ajmer 305817, Rajasthan, India
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 33期
关键词：
Benzylation; Microwave reaction; Catalyst & solvent free; Ethers; Dehydration; SN1; FRIEDEL-CRAFTS CHEMISTRY; 1,3-DICARBONYL COMPOUNDS; BENZYLIC ALCOHOLS; ALLYLIC ALCOHOLS; NUCLEOPHILIC-SUBSTITUTION; PROPARGYLIC ALCOHOLS; METHYLENE-COMPOUNDS; ACTIVE METHYLENES; ALKYLATION; EFFICIENT;
D O I：
10.1016/j.tetlet.2016.07.010
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An expeditious and highly practical, microwave assisted benzylation of naphthols and 4-hydroxycoumarin has been developed under catalyst-free & solvent-free conditions. Alcohols undergo heat induced dehydration to form ethers, which collapse reversibly to form the carbocation which was captured immediately by a suitable nucleophile to furnish the benzylated compounds. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3739 / 3742
页数：4
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