The antidiabetic and antioxidant properties of some phenolic phytochemicals: A review study

Background: One class of phytochemicals are phenols with (-OH) group bounded to aromatic hydrocarbon group. The aim of this study was to review the anti-diabetic and anti-oxidant properties of important phenols. Methods: This is a review study with ethic number (95s108) from AJUMS. About 450 articles (original, review, etc) been screened; 40 of them in the range of (1992-2017) were used due to their correlation to the study purpose. 28 of them were indexed by "Web of science (ISI)", 24 of them indexed by pubmed and also 29 of them were indexed by scopus data center. Findings: Phenols affect diabetes in different ways. CGA suppress hepatic gluconeogenesis through the inhibition of G6Pase and is also an insulin sensitizer that potentiates insulin action. Curcumin reduce insulin resistance so decrease AGE's products in diabetes mellitus. Hydroxytyrosol regulates the calcium channels which plays key role in insulin secretion. Resveratrol increase the stimulation of glucose uptake and insulin secretion. CGA has similar antioxidant activity as vitamin E and ellagic acid maybe is even more potent than vitamin E. curcumin inhibits lipid peroxidation and scavenge superoxide anion and hydroxyl radicals. The antioxidant activity of hydroxytyrosol protects pancreatic cells from damage and death. Treatment with resveratrol significantly decreases the level of glucosylated hemoglobin. Conclusion: All these phytochemicals have potent antidiabetic and antioxidant effects in different ways beside their other effects like anti-inflammatory and anti-carcinogenic properties in ellagic acid, or like anti-angiogenic and apoptogenic activities in curcumin. So we suggest further studies in the field of diabetes and antioxidation. (c) 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.