Role of genotype and precore/basal core promoter mutations of hepatitis B virus in patients with chronic hepatitis B with acute exacerbation

被引:31
作者
Tsai, Wei-Lun [1 ,4 ]
Lo, Gin-Ho [1 ,4 ]
Hsu, Ping-I [1 ,4 ]
Lai, Kwok-Hung [1 ,4 ]
Lin, Chiun-Ku [1 ,4 ]
Chan, Hoi-Hung [1 ,4 ]
Chen, Wen-Chi [1 ,4 ]
Cheng, Jin-Shiung [1 ,4 ]
Liu, Yung-Ching [2 ,4 ]
Huang, Tsi-Shu [2 ,4 ]
Ger, Luo-Ping [3 ]
Lin, Hsi-Hsun [5 ]
机构
[1] Kaosiung Vet Gen Hosp, Dept Internal Med, Div Gastroenterol, Kaohsiung 813, Taiwan
[2] Kaosiung Vet Gen Hosp, Dept Internal Med, Div Microbiol & Infect Dis, Kaohsiung, Taiwan
[3] Kaosiung Vet Gen Hosp, Dept Res & Educ, Kaohsiung, Taiwan
[4] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan
[5] E Da Hosp, Div Microbiol & Infect Dis, Kaohsiung, Taiwan
关键词
acute exacerbation; basal core promoter mutation; genotype; hepatitis B; precore mutation;
D O I
10.1080/00365520701745693
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objctive. The results of long-term, follow-up studies show that the severity and frequency of acute exacerbation of chronic hepatitis B virus (HBV) are associated with the development of liver cirrhosis in chronic HBV infection. The aim of this study was to investigate the relationship between virological factors of HBV and the severity of acute exacerbation. Material and methods. Fifty-one chronic hepatitis B patients with symptomatic acute exacerbation without antiviral therapy were enrolled in the study. Genotype of HBV was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Precore (A1896) and basal core promoter (BCP) mutations (T1762 A1764) were determined by PCR and direct sequencing. Results. Thirty-nine patients had genotype B, 11 patients had genotype C, and 1 patient had an unclassified genotype. Thirty-two patients had precore mutation and 24 patients had BCP mutation. After adjusting for age, gender, aspartate aminotransferase (ASAT) level, albumin level, and platelet count by multiple logistic regression test, precore mutation had a protective effect on the occurrence of hepatic decompensation (p=0.046), and genotype and BCP mutations were not associated with the occurrence of hepatic decompensation. Conclusions. HBV precore mutation may confer less severe liver disease during acute exacerbation of chronic HBV. Genotype and BCP mutations did not have a significant association with the occurrence of hepatic decompensation.
引用
收藏
页码:196 / 201
页数:6
相关论文
共 43 条
[1]   Association of mutations in the core promoter and precore region of hepatitis virus with fulminant and severe acute hepatitis in Japan [J].
Aritomi, T ;
Yatsuhashi, H ;
Fujino, T ;
Yamasaki, K ;
Inoue, O ;
Koga, M ;
Kato, Y ;
Yano, M .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1998, 13 (11) :1125-1132
[2]   Hepatitis B e antigen-negative chronic hepatitis B in Hong Kong [J].
Chan, HLY ;
Leung, NWY ;
Hussain, M ;
Wong, ML ;
Lok, ASF .
HEPATOLOGY, 2000, 31 (03) :763-768
[3]  
Chan HLY, 2002, AM J GASTROENTEROL, V97, P2629, DOI 10.1111/j.1572-0241.2002.06065.x
[4]   Reversion from precore/core promoter mutants to wild-type hepatitis B virus during the course of lamivudine therapy [J].
Cho, SW ;
Hahm, KB ;
Kim, JH .
HEPATOLOGY, 2000, 32 (05) :1163-1169
[5]   THE ETIOLOGY OF ACUTE HEPATITIS SUPERIMPOSED UPON PREVIOUSLY UNRECOGNIZED ASYMPTOMATIC HBSAG-CARRIERS [J].
CHU, CM ;
LIAW, YF ;
PAO, CC ;
HUANG, MJ .
HEPATOLOGY, 1989, 9 (03) :452-456
[6]   Genotype C hepatitis B virus infection is associated with a higher risk of reactivation of hepatitis B and progression to cirrhosis than genotype B: A longitudinal study of hepatitis B e antigen-positive patients with normal aminotransferase levels at baseline [J].
Chu, CM ;
Liaw, YF .
JOURNAL OF HEPATOLOGY, 2005, 43 (03) :411-417
[7]   REACTIVATION OF CHRONIC TYPE-B HEPATITIS PRESENTING AS ACUTE VIRAL-HEPATITIS [J].
DAVIS, GL ;
HOOFNAGLE, JH .
ANNALS OF INTERNAL MEDICINE, 1985, 102 (06) :762-765
[8]   Natural history and prognosis of hepatitis B [J].
Fattovich, G .
SEMINARS IN LIVER DISEASE, 2003, 23 (01) :47-58
[9]   Hepatitis B virus genotypes: Do they play a role in the outcome of HBV infection? [J].
Fung, SK ;
Lok, ASF .
HEPATOLOGY, 2004, 40 (04) :790-792
[10]  
HSU HY, PRECORE MUTANT HEPAT