Induction and temporal changes of osteopontin mRNA and protein in the brain following systemic lipopolysaccharide injection

被引：18

作者：

Choi, JS ^{[1
]}

Park, HJ ^{[1
]}

Cha, JH ^{[1
]}

Chung, JW ^{[1
]}

Chun, MH ^{[1
]}

Lee, MY ^{[1
]}

机构：

[1] Catholic Univ Korea, Coll Med, Dept Anat, Seoul 137701, South Korea

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 141卷 / 1-2期

关键词：

astrocytes; microglia; inflammation; glial limiting membrane;

D O I：

10.1016/S0165-5728(03)00223-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We analyzed expression of osteopontin (OPN), a cytokine regulating tissue repair and inflammation, in astrocytes and microglia in response to systemic lipopolysaccharide (LPS) administration (250 mug/100 g). OPN mRNA expression appeared in subpial astrocytes as early as 6 h, and then spread over the brain parenchyma. The signal for OPN mRNA reached a peak at 24 It post-injection, and returned to basal levels after 48 h. Changes in OPN immunoreactivity in the LPS-injected rat mirrored OPN mRNA induction patterns. These results provide the first evidence of OPN induction in astrocytes and microglia following peripheral immune challenge, and suggest that OPN may play a key role in the pathogenesis of neuroinflammation. (C) 2003 Elsevier B.V All rights reserved.

引用

页码：65 / 73

页数：9

共 36 条

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