Epigenetic gene regulation in the adult mammalian brain: Multiple roles in memory formation

被引：50

作者：

Lubin, Farah D. ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Evelyn F McKnight Brain Inst, Dept Neurobiol, Birmingham, AL 35294 USA

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2011年 / 96卷 / 01期

关键词：

bdnf; NF-kappaB; DNA methylation; Histone methylation; Hippocampus; Amygdala; DNMT; Gadd45; NF-KAPPA-B; LONG-TERM-MEMORY; LINKED MENTAL-RETARDATION; ACTIVE DNA DEMETHYLATION; TEMPORAL-LOBE EPILEPSY; CENTRAL-NERVOUS-SYSTEM; NEUROTROPHIC-FACTOR; SYNAPTIC PLASTICITY; TRANSCRIPTION FACTOR; ALZHEIMERS-DISEASE;

D O I：

10.1016/j.nlm.2011.03.001

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Brain-derived neurotrophic factor (bdnf) is one of numerous gene products necessary for long-term memory formation and dysregulation of bdnf has been implicated in the pathogenesis of cognitive and mental disorders. Recent work indicates that epigenetic-regulatory mechanisms including the markings of histone proteins and associated DNA remain labile throughout the life-span and represent an attractive molecular process contributing to gene regulation in the brain. In this review, important information will be discussed on epigenetics as a set of newly identified dynamic transcriptional mechanisms serving to regulate gene expression changes in the adult brain with particular emphasis on bdnf transcriptional readout in learning and memory formation. This review will also highlight evidence for the role of epigenetics in aberrant bdnf gene regulation in the pathogenesis of cognitive dysfunction associated with seizure disorders, Rett syndrome, Schizophrenia, and Alzheimer's disease. Such research offers novel concepts for understanding epigenetic transcriptional mechanisms subserving adult cognition and mental health, and furthermore promises novel avenues for therapeutic approach in the clinic. (c) 2011 Elsevier Inc. All rights reserved.

引用

页码：68 / 78

页数：11

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