IL-4 receptor α polymorphisms are predictors of a pharmacogenetic response to a novel IL-4/IL-13 antagonist

被引：32
|
作者：
Slager, Rebecca E. [1 ]
Hawkins, Gregory A. [1 ]
Ampleford, Elizabeth J. [1 ]
Bowden, Alexandra [2 ]
Stevens, Lauren E. [2 ]
Morton, Matthew T. [2 ]
Tomkinson, Adrian [2 ]
Wenzel, Sally E. [3 ]
Longphre, Malinda [2 ]
Bleecker, Eugene R. [1 ]
Meyers, Deborah A. [1 ]
机构：
[1] Wake Forest Univ, Bowman Gray Sch Med, Ctr Genom & Personalized Med Res, Winston Salem, NC 27106 USA
[2] Aerovance, Berkeley, CA USA
[3] Univ Pittsburgh, Med Ctr, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA USA
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2010年 / 126卷 / 04期
关键词：
DUTCH POPULATION; ASTHMA; ASSOCIATION; ATOPY; GENE;
D O I：
10.1016/j.jaci.2010.08.001
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
[No abstract available]
引用
收藏
页码：875 / 878
页数：5
相关论文
共 50 条
  • [1] The evolution of IL-4 and IL-13 and their receptor subunits
    Wang, Tiehui
    Secombes, Christopher J.
    CYTOKINE, 2015, 75 (01) : 8 - 13
  • [2] Distinct roles for IL-13 and IL-4 via IL-13 receptor α1 and the type II IL-4 receptor in asthma pathogenesis
    Munitz, A.
    Brandt, E. B.
    Mingler, M.
    Finkelmant, F. D.
    Rothenberg, M. E.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (20) : 7240 - 7245
  • [3] Polymorphisms in the IL-13 and IL-4 receptor alpha genes and allergic rhinitis
    Jeong Joong Kim
    Jung Youl Min
    Jae Hoon Lee
    European Archives of Oto-Rhino-Laryngology, 2007, 264 : 395 - 399
  • [4] Polymorphisms in the IL-13 and IL-4 receptor alpha genes and allergic rhinitis
    Kim, Jeong Joong
    Min, Jung Youl
    Lee, Jae Hoon
    EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2007, 264 (04) : 395 - 399
  • [5] Role of periostin, FENO, IL-13, lebrikzumab, other IL-13 antagonist and dual IL-4/IL-13 antagonist in asthma
    Agrawal, Swati
    Townley, Robert G.
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2014, 14 (02) : 165 - 181
  • [6] Structural similarity of IL-13 and IL-4
    Tang, JCT
    Cannon-Carlson, S
    Varnerin, J
    Tsarbopoulos, A
    Wylie, D
    FASEB JOURNAL, 1997, 11 (09): : A1361 - A1361
  • [7] Mast cell production and response to IL-4 and IL-13
    McLeod, Jamie J. A.
    Baker, Bianca
    Ryan, John J.
    CYTOKINE, 2015, 75 (01) : 57 - 61
  • [8] IL-4 receptor α is an important modulator of IL-4 and IL-13 receptor binding:: Implications for the development of therapeutic targets
    Andrews, Allison-Lynn
    Holloway, John W.
    Holgate, Stephen T.
    Davies, Donna E.
    JOURNAL OF IMMUNOLOGY, 2006, 176 (12): : 7456 - 7461
  • [9] Structure, binding, and antagonists in the IL-4/IL-13 receptor system
    Mueller, TD
    Zhang, JL
    Sebald, W
    Duschl, A
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2002, 1592 (03): : 237 - 250
  • [10] Commentary: IL-4 and IL-13 receptors and signaling
    McCormick, Sarah M.
    Heller, Nicola M.
    CYTOKINE, 2015, 75 (01) : 38 - 50
12345