Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: Orally efficacious antiobesity therapeutics

被引：75

作者：

McBriar, MD ^{[1
]}

Guzik, H ^{[1
]}

Xu, R ^{[1
]}

Paruchova, J ^{[1
]}

Li, SJ ^{[1
]}

Palani, A ^{[1
]}

Clader, JW ^{[1
]}

Greenlee, WJ ^{[1
]}

Hawes, BE ^{[1
]}

Kowalski, TJ ^{[1
]}

O'Neill, K ^{[1
]}

Spar, B ^{[1
]}

Weig, B ^{[1
]}

机构：

[1] Schering Plough Corp, Inst Res, Kenilworth, NJ 07033 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2005年 / 48卷 / 07期

关键词：

D O I：

10.1021/jm049035q

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Melanin concentrating hormone (MCH) is involved in regulation of food intake and energy homeostasis. Antagonists of the MCH receptor are expected to affect food intake and weight gain, making MCH-R1 an attractive target for obesity treatment. Herein, we report the discovery of a novel, orally active series of MCH-R1 antagonists that exhibit in vivo efficacy in rodent obesity models.

引用

页码：2274 / 2277

页数：4

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