A One-Pot Reaction toward the Diastereoselective Synthesis of Substituted Morpholines

被引：22

作者：

Aubineau, Thomas ^{[1
]}

Cossy, Janine ^{[1
]}

机构：

[1] PSL Univ, Lab Chim Organ, Inst Chem Biol & Innovat CBI, UMR 8231,ESPCI Paris,CNRS, 10 Rue Vauquelin, F-75231 Paris 05, France

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 23期

关键词：

STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC-SYNTHESIS; HETEROCYCLES; PIPERAZINES; ACTIVATION;

D O I：

10.1021/acs.orglett.8b03141

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The diastereoselective synthesis of various substituted morpholines has been achieved from vinyloxiranes and amino-alcohols under sequential Pd(0)-catalyzed Tsuji-Trost/Fe(III)-catalyzed heterocyclization. Using the same strategy, 2,6-, 2,5-, and 2,3-disubstituted as well as 2,5,6- and 2,3,5-trisubstituted morpholines were obtained in good to excellent yields and diastereoselectivities.

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收藏

页码：7419 / 7423

页数：5

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