A feasible biocompatible hydrogel film embedding Periplaneta americana extract for acute wound healing

被引：37

作者：

Chen, Zhejie ^{[1
]}

Hu, Yichen ^{[2
]}

Li, Jie ^{[1
]}

Zhang, Chen ^{[1
]}

Gao, Fei ^{[1
]}

Ma, Xuewei ^{[1
]}

Zhang, Jinming ^{[1
]}

Fu, Chaomei ^{[1
]}

Geng, Funeng ^{[3
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Sichuan, Peoples R China

[2] Chengdu Univ, Coll Pharm & Biol Engn, Chengdu, Sichuan, Peoples R China

[3] Sichuan Key Lab Med Amer Cockroach, Chengdu, Sichuan, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2019年 / 571卷

关键词：

Periplaneta americana; Wound healing; Hydrogel film; Acute wound; Scald wound; IN-VITRO; ANTIBACTERIAL ACTIVITY; ALGINATE; CHITOSAN; OPTIMIZATION;

D O I：

10.1016/j.ijpharm.2019.118707

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The wound healing effects of pharmaceutic preparations of Periplaneta americana, Kangfuxin liquid, have been widely utilized in clinics. However, its wound repair efficacy is limited due to short retention capability on cutaneous wound location. Herein, Periplaneta americana extract (PAE), which showed pro-fibrogenic and pro-angiogeneic effects, was embedded into hydrogel film (PAE/Film) by solution cast method by blending polyvinyl alcohol, hydroxypropyl chitosan and carbomer at the weight ratio of 78/6/3, with glycerol as plasticizer. PAE/Film exhibited smooth, flexible, and excellent swelling ability (WVTR of 2464 +/- 31.5 g/m(2)/day), characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and differential scanning calorimetry, meting the condition of ideal wound dressing. The superior wound healing capacity of PAE/Film was demonstrated that it significantly accelerated wound healing process in vivo in both full-thickness skin defect and scald wounded models. Compared to saline, blank vehicle (drug-free) and free PAE group, PAE/Film could accelerate wound healed, promote re-epithelialization and collagen deposition by means of TGF-beta/Smad signal pathway activation. Taken together, this novel hydrogel film-loading PAE would be a useful pharmaceutic candidate for acute cutaneous wound health care.

引用

页数：11

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