Inhibition of duck hepatitis B virus replication by 2',3'-dideoxy-3'-fluoroguanosine in vitro and in vivo

被引：15

作者：

Hafkemeyer, P ^{[1
]}

KepplerHafkemeyer, A ^{[1
]}

AlHaya, MA ^{[1
]}

VonJantaLipinski, M ^{[1
]}

Matthes, E ^{[1
]}

Lehmann, C ^{[1
]}

Offensperger, WB ^{[1
]}

Offensperger, S ^{[1
]}

Gerok, W ^{[1
]}

Blum, HE ^{[1
]}

机构：

[1] MAX DELBRUCK CENTRUM MOLEK MED,D-13125 BERLIN,GERMANY

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 03期

关键词：

D O I：

10.1128/AAC.40.3.792

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The antiviral activity of 2',3'-dideoxy-3'-fluoroguanosine (FdG) or its triphosphate was evaluated in the duck hepatitis B virus (DHBV) system in vitro and in vivo. In primary DHBV-infected hepatocytes FdG results in a dose-dependent inhibition of viral replication with a nearly complete inhibition at a concentration of 1 mu M. Also in vivo, FdG treatment of DHBV-infected ducklings reduces DHBV DNA replication by more than 90%. These data demonstrate that FdG is a strong inhibitor of DHBV replication in vitro and in vivo.

引用

页码：792 / 794

页数：3

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