hepatitis B virus;
famciclovir;
penciclovir;
polymerase;
D O I:
10.1159/000150566
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Famciclovir (FCV, the oral form of penciclovir, PCV) is a potent antiviral agent of hepatitis B virus (HBV) and is currently in phase III clinical trials. In this review, we examine the outcome of FCV treatment in preventing recurrent HBV in patients post transplantation. Resistance to FCV has now been documented in this setting, in which reduced sensitivity to FCV was associated with mutations upstream from the conserved 'YMDD' motif in the HBV polymerase gene. These mutations are in a region which has been designated as the B domain in RNA-dependent polymerases. To understand these mutations we have developed a model of the catalytic regions of the HBV polymerase and located mutations selected during antiviral treatment on this model.
机构:
Capital Med Univ, Beijing Key Lab Translat Med Cirrhosis, Natl Clin Res Ctr Digest Dis, Liver Res Ctr,Beijing Friendship Hosp, 95 Yong An Rd, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Key Lab Translat Med Cirrhosis, Natl Clin Res Ctr Digest Dis, Liver Res Ctr,Beijing Friendship Hosp, 95 Yong An Rd, Beijing 100050, Peoples R China
Tian, Qiuju
Jia, Jidong
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机构:
Capital Med Univ, Beijing Key Lab Translat Med Cirrhosis, Natl Clin Res Ctr Digest Dis, Liver Res Ctr,Beijing Friendship Hosp, 95 Yong An Rd, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Key Lab Translat Med Cirrhosis, Natl Clin Res Ctr Digest Dis, Liver Res Ctr,Beijing Friendship Hosp, 95 Yong An Rd, Beijing 100050, Peoples R China
机构:
Department of Infectious Diseases,School of Medicine,Ondokuz Mayis University,55139 Samsun,TurkeyDepartment of Infectious Diseases,School of Medicine,Ondokuz Mayis University,55139 Samsun,Turkey
机构:
Univ Poonch, Dept Zool, Rawalakot 12350, Azad Jammu & Ka, Pakistan
Pir Mehr Ali Shah Arid Agr Univ, Dept Zool, Rawalpindi 46300, PakistanUniv Poonch, Dept Zool, Rawalakot 12350, Azad Jammu & Ka, Pakistan
Mahmood, Majid
Anwar, Muhammad Asim
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机构:
Pakistan Atom Energy Commiss PAEC Gen Hosp, Dept Gen Med, Islamabad 44000, PakistanUniv Poonch, Dept Zool, Rawalakot 12350, Azad Jammu & Ka, Pakistan
Anwar, Muhammad Asim
Khanum, Azra
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h-index: 0
机构:
BIMS, Rawalpindi 46300, PakistanUniv Poonch, Dept Zool, Rawalakot 12350, Azad Jammu & Ka, Pakistan
Khanum, Azra
Zaman, Nasib
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h-index: 0
机构:
Univ Swat, Ctr Biotechnol & Microbiol, Swat 19130, PakistanUniv Poonch, Dept Zool, Rawalakot 12350, Azad Jammu & Ka, Pakistan
Zaman, Nasib
Raza, Abida
论文数: 0引用数: 0
h-index: 0
机构:
Nucl Med Oncol & Radiotherapy Inst NORI, Diagnost Dept, Islamabad 44000, PakistanUniv Poonch, Dept Zool, Rawalakot 12350, Azad Jammu & Ka, Pakistan
机构:
Capital Med Univ, Beijing Key Lab Translat Med Cirrhosis, Natl Clin Res Ctr Digest Dis, Liver Res Ctr,Beijing Friendship Hosp, 95 Yong An Rd, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Key Lab Translat Med Cirrhosis, Natl Clin Res Ctr Digest Dis, Liver Res Ctr,Beijing Friendship Hosp, 95 Yong An Rd, Beijing 100050, Peoples R China
Tian, Qiuju
Jia, Jidong
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Beijing Key Lab Translat Med Cirrhosis, Natl Clin Res Ctr Digest Dis, Liver Res Ctr,Beijing Friendship Hosp, 95 Yong An Rd, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Key Lab Translat Med Cirrhosis, Natl Clin Res Ctr Digest Dis, Liver Res Ctr,Beijing Friendship Hosp, 95 Yong An Rd, Beijing 100050, Peoples R China
机构:
Department of Infectious Diseases,School of Medicine,Ondokuz Mayis University,55139 Samsun,TurkeyDepartment of Infectious Diseases,School of Medicine,Ondokuz Mayis University,55139 Samsun,Turkey
机构:
Univ Poonch, Dept Zool, Rawalakot 12350, Azad Jammu & Ka, Pakistan
Pir Mehr Ali Shah Arid Agr Univ, Dept Zool, Rawalpindi 46300, PakistanUniv Poonch, Dept Zool, Rawalakot 12350, Azad Jammu & Ka, Pakistan
Mahmood, Majid
Anwar, Muhammad Asim
论文数: 0引用数: 0
h-index: 0
机构:
Pakistan Atom Energy Commiss PAEC Gen Hosp, Dept Gen Med, Islamabad 44000, PakistanUniv Poonch, Dept Zool, Rawalakot 12350, Azad Jammu & Ka, Pakistan
Anwar, Muhammad Asim
Khanum, Azra
论文数: 0引用数: 0
h-index: 0
机构:
BIMS, Rawalpindi 46300, PakistanUniv Poonch, Dept Zool, Rawalakot 12350, Azad Jammu & Ka, Pakistan
Khanum, Azra
Zaman, Nasib
论文数: 0引用数: 0
h-index: 0
机构:
Univ Swat, Ctr Biotechnol & Microbiol, Swat 19130, PakistanUniv Poonch, Dept Zool, Rawalakot 12350, Azad Jammu & Ka, Pakistan
Zaman, Nasib
Raza, Abida
论文数: 0引用数: 0
h-index: 0
机构:
Nucl Med Oncol & Radiotherapy Inst NORI, Diagnost Dept, Islamabad 44000, PakistanUniv Poonch, Dept Zool, Rawalakot 12350, Azad Jammu & Ka, Pakistan