Reduced calcium elevation in hippocampal CA1 neurons of ischemia-tolerant gerbils

被引：41

作者：

Shimazaki, K ^{[1
]}

Nakamura, T

Nakamura, K

Oguro, K

Masuzawa, T

Kudo, Y

Kawai, N

机构：

[1] Jichi Med Sch, Dept Physiol & Neurosurg, Minami Kawachi, Tochigi 3290498, Japan

[2] Tokyo Univ Pharm & Life Sci, Lab Cellular Neurobiol, Hachioji, Tokyo 1920392, Japan

来源：

NEUROREPORT | 1998年 / 9卷 / 08期

关键词：

brain ischemia; Ca2+ imaging; gerbil; hippocampal slice; ischemic tolerance;

D O I：

10.1097/00001756-199806010-00038

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

TRANSIENT forebrain ischemia causes selective neuronal death in the hippocampal CA1 neurons. A short sublethal ischemic episode preceding ischemia of longer duration is known to increase tolerance against cell death. The mechanisms of this ischemic tolerance are still poorly understood. Here we show, using Ca2+ imaging, that intracellular calcium ([Ca2+](i)) elevation in CA1 neurons after an anoxic-aglycemic episode is markedly inhibited in the ischemia-tolerant gerbil. The hippocampus of gerbils which did not acquire tolerance showed a high [Ca2+](i) elevation during the anoxic-aglycemic episode, similar to controls. Since hypoxia/ ischemia-induced neurodegeneration can be triggered by cytoplasmic Ca2+ overload, the tolerant gerbil map regulate calcium and keep [Ca2+](i) below the critical level for initiating neuronal death. (C) 1998 Rapid Science Ltd.

引用

页码：1875 / 1878

页数：4

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