Characterization of folic acid/native cyclodextrins host-guest complexes in solution

被引：31

作者：

Ceborska, Magdalena ^{[1
]}

Zimnicka, Magdalena ^{[2
]}

Wszelaka-Rylik, Malgorzata ^{[3
]}

Troc, Anna ^{[2
]}

机构：

[1] Polish Acad Sci, Inst Phys Chem, PL-01224 Warsaw, Poland

[2] Polish Acad Sci, Inst Organ Chem, Kasprzaka 44-52, PL-01224 Warsaw, Poland

[3] Cardinal Stefan Wyszykski Univ, Fac Biol & Environm Sci, Woycickiego 1-3, PL-01938 Warsaw, Poland

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2016年 / 1109卷

关键词：

Folic acid; Native cyclodextrins; Aggregation in water; Nuclear magnetic resonance; Isothermal Titration Calorimetry; Mass spectrometry; MASS-SPECTROMETRY; PROTONATION CONSTANTS; ASSOCIATION; NMR; PRODRUG; ACID;

D O I：

10.1016/j.molstruc.2015.12.082

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The complexation of folic acid (FA) with native cyclodextrins was studied and this process was used for the comparison of H-1 NMR, ITC and ESIMS for the evaluation of association constants. The stability increases in the series: alpha-cyclodextrin/FA < gamma-cyclodextrin/FA < beta-cyclodextrin/FA. H-1 NMR and ITC gave comparable results in regard to association constant values, while results obtained for MS were considerably higher due to different interactions (electrostatic instead of hydrophobic) responsible for the stabilization of the complexes. The dimerization of FA in water was also studied, as well as its impact on the process of complexation with native cyclodextrins. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：114 / 118

页数：5

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