InCl3 - Catalyzed Synthesis and Anti-cancer Activity of 2-Aryl-1,3,4-Oxadiazoles

被引：0
|
作者：
Saketi, Jagan Mohana Rao [1 ]
Ramanal, M. Baby [1 ]
Alam, M. Mujahid [2 ]
Mule, Siva Nagi Reddy [1 ]
Babu, B. Hari [1 ]
机构：
[1] Acharya Nagarjuna Univ, Dept Chem, Guntur, Andhra Pradesh, India
[2] King Khalid Univ, Coll Sci, Dept Chem, Abha 61413, Saudi Arabia
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2021年 / 31卷 / 03期
关键词：
1,3,4-Oxadiazoles; Acylhydrazines; InCl3; MCF-7; ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; CARBOXYLIC-ACIDS; 1,3,4-OXADIAZOLES; DERIVATIVES; ANTIBACTERIAL; CYCLIZATION; MILD;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2,5-Disubstituted -1,3,4-oxadiazoles were synthesized through one-pot Indium-catalyzed C-N bond formation/cyclisation reaction at 100 degrees C in dimethoxycthane. This methodology allows simple and efficient process for the synthesis of 2,5-disubstituted-1,3,4-oxadiazoles in good to excellent yields from readily available acylhydrazines and acid chlorides. Further, the compounds were studied for anticancer activity on MCF-7 cell line.
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收藏
页码：505 / 509
页数：5
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