Individualized prediction of late-onset dysphagia in head and neck cancer survivors

被引：14

作者：

Aylward, Alana ^{[1
,2
]}

Park, Jihye ^{[3
]}

Abdelaziz, Sarah ^{[1
,2
]}

Hunt, Jason P. ^{[1
,2
]}

Buchmann, Luke O. ^{[1
,2
]}

Cannon, Richard B. ^{[1
,2
]}

Rowe, Kerry ^{[4
]}

Snyder, John ^{[4
]}

Deshmukh, Vikrant ^{[5
]}

Newman, Michael ^{[5
]}

Wan, Yuan ^{[6
]}

Fraser, Alison ^{[6
]}

Smith, Ken ^{[6
]}

Lloyd, Shane ^{[2
,7
]}

Hitchcock, Ying ^{[2
,7
]}

Hashibe, Mia ^{[8
]}

Monroe, Marcus M. ^{[1
,2
]}

机构：

[1] Univ Utah, Sch Med, Dept Otolaryngol Head & Neck Surg, Salt Lake City, UT USA

[2] Huntsman Canc Inst, Salt Lake City, UT USA

[3] Huntsman Canc Inst, Canc Control & Populat Sci, Salt Lake City, UT USA

[4] Intermt Healthcare, Salt Lake City, UT USA

[5] Univ Utah, Hlth Sci Ctr, Salt Lake City, UT USA

[6] Huntsman Canc Inst, Pedigree & Populat Resource, Populat Sci, Salt Lake City, UT USA

[7] Univ Utah, Dept Radiat Oncol, Radiat Oncol, Salt Lake City, UT USA

[8] Univ Utah, Sch Med, Div Publ Hlth, Dept Family & Prevent Med, Salt Lake City, UT USA

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2020年 / 42卷 / 04期

基金：

美国国家卫生研究院;

关键词：

dysphagia; head and neck cancer; late effects; squamous cell carcinoma; survivorship; QUALITY-OF-LIFE; PROPHYLACTIC GASTROSTOMY; SWALLOWING OUTCOMES; TREATMENT MODALITY; RISK-FACTORS; CHEMORADIOTHERAPY; TUBE; ASPIRATION; PNEUMONIA; CARCINOMA;

D O I：

10.1002/hed.26039

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background Limited data exist regarding which head and head and neck cancer (HNC) survivors will suffer from long-term dysphagia. Methods From a population-based cohort of 1901 Utah residents with HNC and >= 3 years follow-up, we determined hazard ratio for dysphagia, aspiration pneumonia, or gastrostomy associated with various risk factors. We tested prediction models with combinations of factors and then assessed discrimination of our final model. Results Cancer site in the hypopharynx, advanced tumor classification, chemoradiation, preexisting dysphagia, stroke, dementia, esophagitis, esophageal spasm, esophageal stricture, gastroesophageal reflux, thrush, or chronic obstructive pulmonary disease were associated with increased risk of long-term dysphagia. Our final prediction tool gives personalized risk calculation for diagnosis of dysphagia, aspiration pneumonia, or gastrostomy tube placement at 5, 10, and 15 years after HNC based on 18 factors. Conclusion We developed a clinically useful risk prediction tool to identify HNC survivors most at risk for dysphagia.

引用

页码：708 / 718

页数：11

共 26 条

[1]

[Anonymous], 2014, OTOLARYNG HEAD NECK, DOI DOI 10.1177/0194599813517081

[2]

[Anonymous], 2013, HEAD NECK

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