Effects of Panax ginseng on Glial Cell-derived Neurotrophic Factor (GDNF) Expression and Spermatogenesis in Rats

被引：22
|
作者：
Yang, Woong Mo [1 ]
Park, Soo Yeon [2 ]
Kim, Hyung-Min [3 ]
Park, Eun Hwa [1 ]
Park, Seong Kyu [1 ]
Chang, Mun Seog [1 ]
机构：
[1] Kyung Hee Univ, Dept Prescriptionol, Coll Oriental Med, Seoul, South Korea
[2] Kyung Hee Univ, Ctr Sports Med, EW Neo Med Ctr, Seoul, South Korea
[3] Kyung Hee Univ, Coll Oriental Med, Inst Oriental Med, Dept Pharmacol, Seoul, South Korea
来源：
PHYTOTHERAPY RESEARCH | 2011年 / 25卷 / 02期
关键词：
glial cell-derived neurotrophic factor (GDNF); male reproductive function; Panax ginseng; spermatogenesis; sperm counts; SPERMATOGONIAL STEM-CELLS; ELEMENT MODULATOR CREM; MALE-INFERTILITY; NICHE;
D O I：
10.1002/ptr.3239
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Panax ginseng (PG) is a medicinal herb which has been used to improve male reproduction in traditional Korean medicine. This study investigated the effect of PG on spermatogenesis and the regulation of glial cell-derived neurotrophic factor (GDNF), which has a crucial role in spermatogonial stem cell maintenance. PG was administered to 8-week-old male Wistar rats (1.0 g/kg/day, p.o.) for 56 consecutive days, the sperm formation period of the rat. Sperm analysis, RT-PCR and western blot assays were then carried out. The PG-treated group had significantly enhanced sperm counts, GDNF mRNA level and protein level. These results suggest that PG induces spermatogenesis and GDNF activation in rat testes. Copyright (C) 2010 John Wiley & Sons, Ltd.
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页码：308 / 311
页数：4
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