An amuse-bouche of stem cell regulation: Underlying principles and mechanisms from adult Drosophila intestinal stem cells

被引：22

作者：

Boumard, Benjamin ^{[1
]}

Bardin, Allison J. ^{[1
]}

机构：

[1] PSL Res Univ, Inst Curie, Stem Cells & Tissue Homeostasis Grp, INSERM,U934,CNRS UMR 3215, Paris, France

来源：

CURRENT OPINION IN CELL BIOLOGY | 2021年 / 73卷

关键词：

EPITHELIAL HOMEOSTASIS; PROLIFERATION; MIDGUT; DIFFERENTIATION; PHYSIOLOGY; DIVERSITY;

D O I：

10.1016/j.ceb.2021.05.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Stem cells have essential functions in the development and maintenance of our organs. Improper regulation of adult stem cells and tissue homeostasis can result in cancers and agedependent decline. Therefore, understanding how tissue-specific stem cells can accurately renew tissues is an important aim of regenerative medicine. The Drosophila midgut harbors multipotent adult stem cells that are essential to renew the gut in homeostatic conditions and upon stress-induced regeneration. It is now a widely used model system to decipher regulatory mechanisms of stem cell biology. Here, we review recent findings on how adult intestinal stem cells differentiate, interact with their environment, and change during aging.

引用

页码：58 / 68

页数：11

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