Genetic Variation in IL28B and Treatment-induced Clearance of Hepatitis C Virus in HIV-Positive Patients With Acute and Chronic Hepatitis C

被引：50

作者：

Nattermann, Jacob ^{[1
]}

Vogel, Martin ^{[1
]}

Nischalke, Hans Dieter ^{[1
]}

Danta, Mark ^{[7
]}

Mauss, Stefan ^{[2
]}

Stellbrink, Hans-Joerg ^{[3
]}

Baumgarten, Axel

Mayr, Christoph

Bruno, Raffaele ^{[8
]}

Tural, Cristina ^{[9
]}

Klausen, Gerd ^{[4
]}

Clotet, Bonaventura ^{[9
]}

Naumann, Uwe ^{[3
]}

Lutz, Thomas ^{[5
]}

Rausch, Michael

Schewe, Knud

Bienek, Bernhard

Haerter, Georg ^{[6
]}

Sauerbruch, Tilman ^{[1
]}

Rockstroh, Juergen K. ^{[1
]}

Spengler, Ulrich ^{[1
]}

机构：

[1] Univ Bonn, Dept Internal Med 1, D-53105 Bonn, Germany

[2] Ctr HIV & Hepatogastroenterol, Dusseldorf, Germany

[3] ICH, Hamburg, Germany

[4] Praxiszentrum Kaiserdamm, Berlin, Germany

[5] HIV Cohort Frankfurt, Frankfurt, Germany

[6] Univ Hosp & Med Ctr, Dept Internal Med, Div Infect Dis, Ulm, Germany

[7] St Vincents Clin Sch, Dept Med UNSW, Melbourne, Vic, Australia

[8] Univ Pavia, IRCCS, San Matteo Hosp, Div Infect & Trop Dis,Hepatol Outpatients Unit, I-27100 Pavia, Italy

[9] Univ Autonoma Barcelona, Univ Hosp Germans Trias & Pujol, HIV Clin Unit Dept, E-08193 Barcelona, Spain

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 203卷 / 05期

关键词：

PEGYLATED INTERFERON-ALPHA; ASSOCIATION; COINFECTION; THERAPY;

D O I：

10.1093/infdis/jiq098

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recently, a IL28B (rs 12979860) gene polymorphism was identified as a predictor for response to hepatits C virus-specific treatment in human immunodeficiency virus (HIV)-uninfected and -infected patients with chronic hepatitis C. In an analysis of HIV-infected patients with acute hepatitis C, we found that the IL28B genotype was associated with serum levels of hepatitis C virus RNA, g-GT, and CD4 cell count. In contrast to HIV-infected patients with chronic hepatitis C, the IL28B genotype was not significantly associated with treatment response rates in patients with acute hepatitis C. Thus, effects of the IL28B single-nucleotide polymorphism may differ in HIV-infected patients with chronic and acute hepatitis C.

引用

页码：595 / 601

页数：7

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