Accumulation of gliotoxin, a cytotoxic mycotoxin from Aspergillus fumigatus, in blue mussel (Mytilus edulis)

被引：37

作者：

Grovel, O ^{[1
]}

Pouchus, YF ^{[1
]}

Verbist, JF ^{[1
]}

机构：

[1] Univ Nantes, Fac Pharm, SMAB, F-44035 Nantes 01, France

来源：

TOXICON | 2003年 / 42卷 / 03期

关键词：

gliotoxin; mussel; accumulation; seafood safety; Aspergillus fumigatus; marine fungi;

D O I：

10.1016/S0041-0101(03)00146-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A strain of Aspergillus fumigatus has been isolated from sediments of a mussel bed. When cultured in hyper saline conditions (with sea-water), it produces a cytotoxic and immunosuppressive toxin, gliotoxin, which is excreted in an exudate. In order to know if this toxin could represent a risk for shellfish consumers, an experiment of bioaccumulation of gliotoxin in mussel has been carried out. After 6 days of contamination, toxin was accumulated in the meat of the mussels, at a level up to 2.9 mug/mg of extract weight. with a mode of contamination different to the classical digestive process described for a majority of marine toxins, but similar to the contamination mode of domoic acid. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：297 / 300

页数：4

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