DNA-capped nanoparticles designed for doxorubicin drug delivery

被引：71

作者：

Alexander, Colleen M. ^{[1
]}

Maye, Mathew M. ^{[1
]}

Dabrowiak, James C. ^{[1
]}

机构：

[1] Syracuse Univ, Dept Chem, Syracuse, NY 13244 USA

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 12期

关键词：

GOLD NANOPARTICLES; ANTIBIOTICS; SPECIFICITY; DAUNOMYCIN; TOXICITY; RELEASE; BINDING;

D O I：

10.1039/c0cc04916f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The anticancer drug, doxorubicin (DOX), was loaded onto DNA-capped gold nanoparticles (AuNP) designed for specific DOX intercalation. Drug binding was confirmed by monitoring DNA melting temperature, AuNP plasmon resonance maximum, and hydrodynamic radius increase, as a function of [DOX]/[DNA] ratio. The capacity for drug release to target DNA was confirmed.

引用

页码：3418 / 3420

页数：3

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