Elevated Pro-Brain Natriuretic Peptide, Troponin T and Malnutrition Inflammatory Score in Chronic Hemodialysis Patients with Overt Cardiovascular Disease

被引：10

作者：

Trimarchi, Hernan ^{[1
]}

Muryan, Alexis ^{[2
]}

Campolo-Girard, Vicente ^{[1
]}

Dicugno, Mariana ^{[2
]}

Barucca, Nanci ^{[3
]}

Lombi, Fernando ^{[1
]}

Young, Pablo ^{[4
]}

Pomeranz, Vanesa ^{[1
]}

Forrester, Mariano ^{[1
]}

Alonso, Mirta ^{[2
]}

Iriarte, Romina ^{[1
]}

Luisa Diaz, Marisa ^{[5
]}

Lindholm, Bengt ^{[6
]}

机构：

[1] Hosp Britan Buenos Aires, Serv Nephrol, RA-1280 Buenos Aires, DF, Argentina

[2] Hosp Britan Buenos Aires, Cent Lab, RA-1280 Buenos Aires, DF, Argentina

[3] Hosp Britan Buenos Aires, Serv Alimentac, RA-1280 Buenos Aires, DF, Argentina

[4] Hosp Britan Buenos Aires, Serv Clin Med, RA-1280 Buenos Aires, DF, Argentina

[5] Hosp Britan Buenos Aires, Nucl Med Serv, RA-1280 Buenos Aires, DF, Argentina

[6] Karolinska Inst, Baxter Novum, Stockholm, Sweden

来源：

NEPHRON CLINICAL PRACTICE | 2011年 / 117卷 / 03期

关键词：

Pro-brain natriuretic peptide; Troponin T; Inflammation; Malnutrition; Malnutrition inflammatory score; Hemodialysis; Cardiovascular disease; End-stage renal disease; CHRONIC KIDNEY-DISEASE; STAGE RENAL-DISEASE; MARKERS EVALUATION CHANCE; LEFT-VENTRICULAR MASS; HEART-FAILURE; MAINTENANCE HEMODIALYSIS; PERITONEAL-DIALYSIS; PREDICTS MORTALITY; CONTROLLED-TRIAL; CARDIAC-DISEASE;

D O I：

10.1159/000320195

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background: We assessed the relationship between probrain natriuretic peptide (pro-BNP), troponin T (TropT) and nutritional status. Methods: A total of 48 chronic hemodialysis patients were grouped according to the presence [group A (GA); n = 24] or not [group B (GB)] of cardiovascular disease. Results: Compared to GB subjects, GA subjects were older, had been on hemodialysis for a longer period and had higher prevalences of vascular grafts, hypertension and elevated C-reactive protein (CRP) [GA vs. GB: 1.1 (range 0.1-32.9) vs. 0.4 (0-28.1) mg/dl; p = 0.028], malnutrition inflammatory score (MIS) (GA vs. GB: 7.50 vs. 4.00; p = 0.001), pro-BNP [GA vs. GB: 6,760 (601-103,200) vs. 686 (75-83,700) pg/ml; p < 0.001] and TropT [GA vs. GB: 0.3650 (0.011-0.199) vs. 0.010 (0.0-0.290) ng/ml; p = 0.002]. Pro-BNP correlated with TropT (rho 0.539; p < 0.001), MIS (rho 0.502; p < 0.0001), homocysteine (rho 0.321; p = 0.13) and CRP (rho 0.511; p < 0.0001). Pro-BNP levels were lower in GB patients as the body mass index increased; the opposite occurred in GA. Conclusions: Patients with cardiovascular disease had elevated pro-BNP and TropT levels. In patients without cardiovascular disease, malnutrition and inflammation were associated with vascular prostheses, while pro-BNP was lower in obese patients. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：C198 / C205

页数：8

共 58 条

[1]

Acchiardo SR, 1983, KIDNEY INT S, V16, pS199

[2] Biomarkers in heart failure [J].

Braunwald, Eugene .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (20) :2148-2159

[3] Comparison of the prognostic usefulness of N-terminal pro-brain natriuretic peptide in patients with heart failure with versus without chronic kidney disease [J].

Bruch, Christian ;

Fischer, Claudia ;

Sindermann, Juergen ;

Stypmann, Joerg ;

Breithardt, Guenter ;

Gradaus, Rainer .

AMERICAN JOURNAL OF CARDIOLOGY, 2008, 102 (04) :469-474

[4]

BRUNNER FP, 2002, KIDNEY INT S38, V42, pS4

[5] Intradialytic parenteral nutrition does not improve survival in malnourished hemodialysis patients: A 2-year multicenter, prospective, randomized study [J].

Cano, Noel J. M. ;

Fouque, Denis ;

Roth, Hubert ;

Aparicio, Michel ;

Azar, Raymond ;

Canaud, Bernard ;

Chauveau, Philippe ;

Combe, Christian ;

Laville, Maurice ;

Leverve, Xavier M. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2007, 18 (09) :2583-2591

[6] Atherosclerotic cardiovascular disease risks in chronic hemodialysis patients [J].

Cheung, AK ;

Sarnak, MJ ;

Yan, GF ;

Dwyer, JT ;

Heyka, RJ ;

Rocco, MV ;

Teehan, BP ;

Levey, AS .

KIDNEY INTERNATIONAL, 2000, 58 (01) :353-362

[7] Cardiac troponin T and C-reactive protein for predicting prognosis, coronary atherosclerosis, and cardiomyopathy in patients undergoing long-term hemodialysis [J].

deFilippi, C ;

Wasserman, S ;

Rosanio, S ;

Tiblier, E ;

Sperger, H ;

Tocchi, M ;

Christenson, R ;

Uretsky, B ;

Smiley, M ;

Gold, J ;

Muniz, H ;

Badalamenti, J ;

Herzog, C ;

Henrich, W .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (03) :353-359

[8] Plasma atrial natriuretic peptide and natriuretic peptide receptor gene expression in adipose tissue of normotensive and hypertensive obese patients [J].

Dessì-Fulgheri, P ;

Sarzani, R ;

Tamburrini, P ;

Moraca, A ;

Espinosa, E ;

Cola, G ;

Giantomassi, L ;

Rappelli, A .

JOURNAL OF HYPERTENSION, 1997, 15 (12) :1695-1699

[9] Cardiac troponin T predicts mortality in patients with end-stage renal disease [J].

Dierkes, J ;

Domröse, U ;

Westphal, S ;

Ambrosch, A ;

Bosselmann, HP ;

Neumann, KH ;

Luley, C .

CIRCULATION, 2000, 102 (16) :1964-1969

[10] Changes in adiponectin and the risk of sudden death, stroke, myocardial infarction, and mortality in hemodialysis patients [J].

Drechsler, Christiane ;

Krane, Vera ;

Winkler, Karl ;

Dekker, Friedo W. ;

Wanner, Christoph .

KIDNEY INTERNATIONAL, 2009, 76 (05) :567-575

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