High viral loads of human papillomavirus predict risk of invasive cervical carcinoma

被引：108

作者：

Moberg, M ^{[1
]}

Gustavsson, I ^{[1
]}

Wilander, E ^{[1
]}

Gyllensten, U ^{[1
]}

机构：

[1] Uppsala Univ, Dept Genet & Pathol, Rudbeck Lab, S-75185 Uppsala, Sweden

来源：

BRITISH JOURNAL OF CANCER | 2005年 / 92卷 / 05期

关键词：

human papillomavirus; invasive cervical cancer; viral load;

D O I：

10.1038/sj.bjc.6602436

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

High loads of human papillomavirus (HPV) 16 and HPV 18/45 increase the risk of developing invasive cervical carcinoma, revealing higher risk in percentiles of highest viral loads for HPV 16 (odds ratio (OR) 58.7, 95% confidence interval (CI) 21.9-151.4) compared to HPV 18/45 (OR 3.3, 95% CI 1.5-7.2). Thus, HPV load is a type-dependent risk marker for invasive carcinoma.

引用

页码：891 / 894

页数：4

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