Decreased vascular reactivity of portal vein in rats with portal hypertension

被引:9
作者
Huang, YT
Lin, HC
Yu, PC
Lee, FY
Tsai, YT
Lee, SD
Yang, MCM
机构
[1] VET GEN HOSP,DEPT MED,DIV GASTROENTEROL,TAIPEI 11217,TAIWAN
[2] VET GEN HOSP,DEPT MED RES,TAIPEI 11217,TAIWAN
[3] NATL YANG MING UNIV,SCH MED,INST TRADIT MED,TAIPEI,TAIWAN
关键词
cyclic nucleotide; intracellular calcium; portal hypertension; portal vein;
D O I
10.1016/S0168-8278(96)80029-8
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aims: Vascular hyporesponsiveness in portal hypertension is well documented in the arterial tissue. The present study aimed to investigate the possible changes in the portal vein from portal hypertensive rats. Methods: Portal hypertension was induced by partial portal vein ligation. Fourteen days after surgery, portal veins were removed for contractile study and measurement of cAMP, cGMP and [Ca2+](i). Results: In vitro tension preparation showed a decreased maximum response to norepinephrine in portal vein of portal vein ligated rats (38.3+/-4.1 vs, 23.4+/-1.5 mN/mm(2)). The pA(2) values of WB4101 and yohimbine (alpha(1)- and alpha(2)-adrenoceptor antagonist, respectively) were not different between the two groups. Tissue cAMP (14.4+/-0.9 vs, 12.2+/-0.7 pmol/mg protein), but not cGMP, content was increased and intracellular calcium [Ca2+](i) levels (247+/-9 vs. 281+/-13 nM) were decreased in portal vein ligated rats. Conclusions: These results showed that in portal vein from portal vein ligated rats, vascular hyporesponsiveness and an increase in basal cAMP content and a decrease in basal [Ca2+](i) were observed.
引用
收藏
页码:194 / 199
页数:6
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