Cutoff values for HOMA-IR associated with metabolic syndrome in the Study of Cardiovascular Risk in Adolescents (ERICA Study)

被引：26

作者：

Caxiano Chissini, Rafaelle de Barros ^{[1
]}

Kuschnir, Maria Cristina ^{[1
,2
]}

de Oliveira, Cecilia Lacroix ^{[3
]}

Giannini, Denise Tavares ^{[4
]}

Santos, Braulio ^{[5
]}

机构：

[1] Univ Estado Rio de Janeiro, Fac Ciencias Med, Programa Posgrad Ciencias Med, Rio De Janeiro, Brazil

[2] Univ Estacio Sa, Fac Med, Rio De Janeiro, Brazil

[3] Univ Estado Rio de Janeiro, Inst Nutr, Rio De Janeiro, Brazil

[4] Univ Estado Rio de Janeiro, Nucleo Estudos Saude Adolescente, Rio De Janeiro, Brazil

[5] Minist Saude, Inst Nacl Cardiol, BR-22240006 Rio De Janeiro, Brazil

来源：

NUTRITION | 2020年 / 71卷

关键词：

insulin resistance; representative sample; adolescents; sex; Brazil; HOMEOSTATIC MODEL ASSESSMENT; TYPE-2; DIABETES-MELLITUS; FASTING PLASMA-GLUCOSE; INSULIN-RESISTANCE; CHILDREN; IDENTIFY; INDEX; SENSITIVITY; VALIDATION; OVERWEIGHT;

D O I：

10.1016/j.nut.2019.110608

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Objective: The aim of this study was to determine the distribution of homeostatic model assessment of insulin resistance (HOMA-IR) values and define its cutoff associated with metabolic syndrome (MetS) in the participants of the Study of Cardiovascular Risk in Adolescents (Estudo de Risco Cardiovascular em Adolescentes). Methods: MetS was defined according to the International Diabetes Federation criteria. HOMA-IR values were calculated and tabulated by corresponding percentiles for age and sex. Receiver operating characteristic curves were constructed to identify the optimal cutoff values of HOMA-IR associated with MetS in the total population and by sex. Results: We evaluated 37 815 adolescents ages 12 to 17 y. The highest HOMA-IR medians were found among girls and boys ages 12 and 14 y, respectively. Thereafter, values tended to decrease with age. The optimal cutoff values of the HOMA-IR associated with MetS in the total population, in female adolescents, and in male adolescents were 2.80, 232, and 2.87, respectively. Insulin resistance was prevalent in 19.1% (95% confidence interval, 17.7-20.7) of the total population, and the prevalence was higher among girls and overweight Brazilian adolescents. Conclusions: These findings may serve as new reference points for detecting insulin resistance in Brazilian adolescents. (C) 2019 Elsevier Inc. All rights reserved.

引用

页数：6

共 41 条

[1]

[Anonymous], ARQ BRAS ENDOCRINOL

[2] Homeostatic model assessment of insulin resistance as a predictor of metabolic syndrome: Consequences of obesity in children and adolescents [J].

Barseem, Naglaa Fathy ;

Helwa, Mohamed Ahmed .

EGYPTIAN PEDIATRIC ASSOCIATION GAZETTE, 2015, 63 (01) :19-24

[3] The study of cardiovascular risk in adolescents - ERICA: rationale, design and sample characteristics of a national survey examining cardiovascular risk factor profile in Brazilian adolescents [J].

Bloch, Katia Vergetti ;

Szklo, Moyses ;

Kuschnir, Maria Cristina C. ;

Abreu, Gabriela de Azevedo ;

Barufaldi, Laura Augusta ;

Klein, Carlos Henrique ;

de Vasconcelos, Mauricio T. L. ;

da Veiga, Gloria Valeria ;

Figueiredo, Valeska C. ;

Dias, Adriano ;

Pantoja Moraes, Ana Julia ;

Lima Souza, Ana Luiza ;

Andrade de Oliveira, Ana Mayra ;

Schaan, Beatriz D'Argord ;

Tavares, Bruno Mendes ;

de Oliveira, Cecilia Lacroix ;

Cunha, Cristiane de Freitas ;

Giannini, Denise Tavares ;

Belfort, Dilson Rodrigues ;

Barboza Ribas, Dulce Lopes ;

Santos, Eduardo Lima ;

de Leon, Elisa Brosina ;

Fujimori, Elizabeth ;

Arauio Oliveira, Elizabete Regina ;

Magliano, Erika da Silva ;

Guedes Vasconcelos, Francisco de Assis ;

Azevedo, George Dantas ;

Brunken, Gisela Soares ;

Dias, Glauber Monteiro ;

Correa Filho, Heleno R. ;

Monteiro, Maria Ines ;

Britto Guimaraes, Isabel Cristina ;

Faria Neto, Jose Rocha ;

Oliveira, Juliana Souza ;

de Carvalho, Kenia Mara B. ;

de Oliveira Goncalves, Luis Gonzaga ;

Santos, Marize M. ;

Muniz, Pascoal Torres ;

Veiga Jardim, Paulo Cesar B. ;

Muniz Ferreira, Pedro Antonio ;

Montenegro, Renan Magalhaes, Jr. ;

Gurgel, Ricardo Queiroz ;

Vianna, Rodrigo Pinheiro ;

Vasconcelos, Sandra Mary ;

da Matta, Sandro Silva ;

Seixas Martins, Stella Maris ;

Lederer Goldberg, Tamara Beres ;

Nogueira da Silva, Thiago Luiz .

BMC PUBLIC HEALTH, 2015, 15

[4] Study of Cardiovascular Risk Factors in Adolescents (ERICA): results and potentiality [J].

Bloch, Katia Vergetti ;

Cardoso, Marly Augusto ;

Sichieri, Rosely .

REVISTA DE SAUDE PUBLICA, 2016, 50 :3-5

[5] Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors [J].

Burrows, R. ;

Correa-Burrows, P. ;

Reyes, M. ;

Blanco, E. ;

Albala, C. ;

Gahagan, S. .

JOURNAL OF DIABETES RESEARCH, 2015, 2015

[6] Adolescent Growth and Development [J].

Chulani, Veenod L. ;

Gordon, Lonna P. .

PRIMARY CARE, 2014, 41 (03) :465-+

[7]

Cureau FV, 2017, CAD SAUDE PUBLICA, V33, DOI [10.1590/0102-311X00122816, 10.1590/0102-311x00122816]

[8] Development of a WHO growth reference for school-aged children and adolescents [J].

de Onis, Mercedes ;

Onyango, Adelheid W. ;

Borghi, Elaine ;

Siyam, Amani ;

Nishida, Chizuru ;

Siekmann, Jonathan .

BULLETIN OF THE WORLD HEALTH ORGANIZATION, 2007, 85 (09) :660-667

[9]

Fletcher RH, 2006, Epidemiologia Clinica - Elementos Essenciais, V4th, P63

[10] HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome - Brazilian Metabolic Syndrome Study (BRAMS) [J].

Geloneze, Bruno ;

Junquelra Vasques, Ana Carolina ;

Camargo Stabe, Christiane Franca ;

Pareja, Jose Carlos ;

Paez de Lima Rosado, Lina Enriqueta Frandsen ;

de Queiroz, Elaine Cristina ;

Tambascia, Marcos Antonio .

ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA, 2009, 53 (02) :281-287

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