Tetrahydroxystilbene glucoside, a plant-derived cognitive enhancer, promotes hippocampal synaptic plasticity

被引：46
|
作者：
Wang, Ting [1 ]
Yang, Yuan-Jian [1 ]
Wu, Peng-Fei [1 ]
Wang, Wei [1 ]
Hu, Zhuang-Li [1 ,2 ,3 ]
Long, Li-Hong [1 ,2 ,3 ]
Xie, Na [1 ,2 ,3 ]
Fu, Hui [1 ,2 ,3 ]
Wang, Fang [1 ,2 ,3 ]
Chen, Jian-Guo [1 ,2 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Dept Pharmacol, Tonji Med Coll, Wuhan 430030, Peoples R China
[2] Minist Educ China, Key Lab Neurol Dis HUST, Wuhan 430030, Hubei, Peoples R China
[3] Hubei Key Lab Nat Drug Chem & Evaluat HUST, Wuhan 430030, Peoples R China
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2011年 / 650卷 / 01期
基金：
中国国家自然科学基金;
关键词：
2 3 5 4 ' Tetrahydroxystilbene 2 O beta-D-glucoside; Synaptic plasticity; Calcium/calmodulin dependent protein kinase II; Extracellular signal regulated kinase; LONG-TERM POTENTIATION; ACTIVATED PROTEIN-KINASE; ALZHEIMERS-DISEASE; MEMORY; LTP; PHOSPHORYLATION; MECHANISMS; EXTRACT; CASCADE; SEARCH;
D O I：
10.1016/j.ejphar.2010.10.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Plant or food derived polyphenols have received a great deal of attention due to their biological properties including anti-oxidative effects neuroprotection and memory enhancement Here we investigated the roles of 23 5 4'-tetrahydroxystilbene-2-O beta D-glucoside (TSG) an active component of the rhizome extracted from Polygonum multiflorum in the regulation of hippocampal synaptic plasticity in normal mice as well as the underlying mechanisms It was shown that TSG promoted the differentiation of PC12 cells and increased the intracellular calcium level in hippocampal neurons TSG facilitated high frequency stimulation (HFS) induced hippocampal long-term potentiation (LTP) in a bell-shaped manner The facilitation of LW induction by TSG required calcium/calmodulin-dependent protein kinase II (CaMKII) and extracellular signal-regulated kinase (ERK) activation Taken together our data demonstrate that TSG promotes LTP induction and this effect may contribute to the enhancement of learning and memory seen in animal models (C) 2010 Elsevier B V All rights reserved
引用
收藏
页码：206 / 214
页数：9
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