Levetiracetam monotherapy in Alzheimer patients with late-onset seizures: a prospective observational study

被引：67
作者：
Belcastro, V.
Costa, C.
Galletti, F.
Pisani, F.
Calabresi, P.
Parnetti, L. [1 ]
机构：
[1] Univ Perugia, Osped S Maria Misericordia, I-06156 Perugia, Italy
[2] Univ Messina, Policlin Univ, Messina, Italy
[3] Fdn Santa Lucia, IRCCS, Rome, Italy
来源：
EUROPEAN JOURNAL OF NEUROLOGY | 2007年 / 14卷 / 10期
关键词：
Alzheimer's disease; antiepileptic drugs; dementia; late-onset seizures; levetiracetam;
D O I：
10.1111/j.1468-1331.2007.01907.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Levetiracetam (LEV) monotherapy was investigated in 25 patients with advanced Alzheimer's disease (AD) and new-onset epileptic seizures in a prospective open-label study. At a daily dose of 1000-1500 mg, 72% were seizure-free for at least one year; 16% discontinued for untolerability; 8% were unresponsive; 4% were lost to follow-up. These results suggest the need for controlled studies to confirm if LEV can be a first-choice drug in AD.
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收藏
页码：1176 / 1178
页数：3
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共 11 条
  • [1] Incidence and predictors of seizures in patients with Alzheimer's disease
    Amatniek, JC
    Hauser, WA
    DelCastillo-Castaneda, C
    Jacobs, DM
    Marder, K
    Bell, K
    Albert, M
    Brandt, J
    Stern, Y
    [J]. EPILEPSIA, 2006, 47 (05) : 867 - 872
  • [2] Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy
    Brodie, M. J.
    Perucca, E.
    Ryvlin, P.
    Ben-Menachem, E.
    Meencke, H. -J.
    [J]. NEUROLOGY, 2007, 68 (06) : 402 - 408
  • [3] Effect of antiepileptic drugs on cognitive function in individuals with epilepsy - A comparative review of newer versus older agents
    Brunbech, L
    Sabers, A
    [J]. DRUGS, 2002, 62 (04) : 593 - 604
  • [4] Effects of levetiracetam on nocturnal sleep and daytime vigilance in healthy volunteers
    Cicolin, A
    Magliola, U
    Giordano, A
    Terreni, A
    Bucca, C
    Mutani, R
    [J]. EPILEPSIA, 2006, 47 (01) : 82 - 85
  • [5] Limitations of monotherapy trials in epilepsy
    Gilliam, FG
    [J]. NEUROLOGY, 2003, 60 (11) : S26 - S30
  • [6] Epilepsy in the elderly
    Leppik, Ilo E.
    [J]. EPILEPSIA, 2006, 47 : 65 - 70
  • [7] Cognitive and memory effects of the new antiepileptic drugs
    Meador, KJ
    [J]. EPILEPSY RESEARCH, 2006, 68 (01) : 63 - 67
  • [8] Clinical pharmacokinetics of new-generation antiepileptic drugs at the extremes of age
    Perucca, E
    [J]. CLINICAL PHARMACOKINETICS, 2006, 45 (04) : 351 - 363
  • [9] Special considerations in treating the elderly patient with epilepsy
    Ramsay, RE
    Rowan, AJ
    Pryor, FM
    [J]. NEUROLOGY, 2004, 62 (05) : S24 - S29
  • [10] ADVANCED ALZHEIMERS-DISEASE IS A RISK FACTOR FOR LATE-ONSET SEIZURES
    ROMANELLI, MF
    MORRIS, JC
    ASHKIN, K
    COBEN, LA
    [J]. ARCHIVES OF NEUROLOGY, 1990, 47 (08) : 847 - 850
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