Levetiracetam monotherapy in Alzheimer patients with late-onset seizures: a prospective observational study

被引：68

作者：

Belcastro, V.

Costa, C.

Galletti, F.

Pisani, F.

Calabresi, P.

Parnetti, L. ^{[1
]}

机构：

[1] Univ Perugia, Osped S Maria Misericordia, I-06156 Perugia, Italy

[2] Univ Messina, Policlin Univ, Messina, Italy

[3] Fdn Santa Lucia, IRCCS, Rome, Italy

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2007年 / 14卷 / 10期

关键词：

Alzheimer's disease; antiepileptic drugs; dementia; late-onset seizures; levetiracetam;

D O I：

10.1111/j.1468-1331.2007.01907.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Levetiracetam (LEV) monotherapy was investigated in 25 patients with advanced Alzheimer's disease (AD) and new-onset epileptic seizures in a prospective open-label study. At a daily dose of 1000-1500 mg, 72% were seizure-free for at least one year; 16% discontinued for untolerability; 8% were unresponsive; 4% were lost to follow-up. These results suggest the need for controlled studies to confirm if LEV can be a first-choice drug in AD.

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收藏

页码：1176 / 1178

页数：3

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