Selective Detection of Bacteria in Urine with a LRSPP Waveguide Biosensor

被引：0

作者：

Beland, Paul ^{[1
]}

Berini, Pierre ^{[2
,3
]}

Krupin, Oleksiy ^{[4
]}

机构：

[1] Univ Ottawa, Dept Biomed Engn, Ottawa, ON, Canada

[2] Univ Ottawa, Dept Phys, Sch Elect Engn & Comp Sci, Ottawa, ON, Canada

[3] Univ Ottawa, Ctr Res Photon, Ottawa, ON, Canada

[4] Univ Ottawa, Dept Biol & Chem Engn Sci, Ottawa, ON, Canada

来源：

2015 PHOTONICS NORTH | 2015年

关键词：

surface plasmon polaritons; urine; biosensor; bacteria;

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Laboratory experimentation demonstrates long range surface plasmon polaritons (LRSPP) waveguides as a useful biosensor to selectively detect gram negative bacteria in human urine. The biosensor can detect bacteria at concentrations of 10(5) CFU/ml, the internationally recommended threshold for diagnostic of urinary tract infection (UTI). Using a negative control solution at bacterial concentration 1000x higher than the targeted bacteria in urine with a weak concentration of constituents, the power ratio between the negative control signal to the target bacteria signal is measured to be 6.7 on the first test and 2.5 for a lower bacterial concentration after regenerating the surface with SDS. Hence we report a conclusive demonstration of the LRSPP waveguide biosensor selectivity to the gram of bacteria in human urine.

引用

页数：1

共 4 条

[1] Fabrication of surface plasmon waveguides and devices in Cytop with integrated microfluidic channels [J].

Chiu, Charles ;

Lisicka-Skrzek, Ewa ;

Tait, R. Niall ;

Berini, Pierre .

JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B, 2010, 28 (04) :729-735

[2] Biosensing using straight long-range surface plasmon waveguides [J].

Krupin, Oleksiy ;

Asiri, Hamoudi ;

Wang, Chen ;

Tait, R. Niall ;

Berini, Pierre .

OPTICS EXPRESS, 2013, 21 (01) :698-709

[3] The Diagnosis of Urinary Tract Infection A Systematic Review [J].

Schmiemann, Guido ;

Kniehl, Eberhardt ;

Gebhardt, Klaus ;

Matejczyk, Martha M. ;

Hummers-Pradier, Eva .

DEUTSCHES ARZTEBLATT INTERNATIONAL, 2010, 107 (21) :361-U9

[4] Long-range surface plasmons for sensitive detection of bacterial analytes [J].

Vala, M. ;

Etheridge, S. ;

Roach, J. A. ;

Homola, J. .

SENSORS AND ACTUATORS B-CHEMICAL, 2009, 139 (01) :59-63

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