Inferring Past Environments from Ancient Epigenomes

被引：28

作者：

Gokhman, David ^{[1
]}

Malul, Anat ^{[1
]}

Carmel, Liran ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Dept Genet, Fac Sci, Edmond J Safra Campus, Jerusalem, Israel

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 2017年 / 34卷 / 10期

基金：

以色列科学基金会;

关键词：

ancient DNA; ancient epigenetics; DNA methylation; environmental paleoepigenetics; environmental epigenetics; paleoepigenetics; GESTATIONAL DIABETES-MELLITUS; DNA METHYLATION; EPIGENETIC DYSREGULATION; METASTABLE EPIALLELES; GENOMIC INSIGHTS; YERSINIA-PESTIS; EXPOSURE; NEANDERTHAL; BIRTH; ADAPTATION;

D O I：

10.1093/molbev/msx211

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analyzing the conditions in which past individuals lived is key to understanding the environments and cultural transitions to which humans had to adapt. Here, we suggest a methodology to probe into past environments, using reconstructed premortem DNA methylation maps of ancient individuals. We review a large body of research showing that differential DNA methylation is associated with changes in various external and internal factors, and propose that loci whose DNA methylation level is environmentally responsive could serve as markers to infer about ancient daily life, diseases, nutrition, exposure to toxins, and more. We demonstrate this approach by showing that hunger-related DNA methylation changes are found in ancient hunter-gatherers. The strategy we present here opens a window to reconstruct previously inaccessible aspects of the lives of past individuals.

引用

页码：2429 / 2438

页数：10

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