A Multimodal System with Synergistic Effects of Magneto-Mechanical, Photothermal, Photodynamic and Chemo Therapies of Cancer in Graphene-Quantum Dot-Coated Hollow Magnetic Nanospheres

被引:72
作者
Wo, Fangjie [1 ]
Xu, Rujiao [1 ]
Shao, Yuxiang [1 ]
Zhang, Zheyu [1 ]
Chu, Maoquan [1 ]
Shi, Donglu [1 ,2 ]
Liu, Shupeng [3 ]
机构
[1] Tongji Univ, Sch Life Sci & Technol, Shanghai East Hosp, Res Ctr Translat Med, Shanghai 200092, Peoples R China
[2] Univ Cincinnati, Coll Engn & Appl Sci, Dept Mech & Mat Engn, Mat Sci & Engn Program, Cincinnati, OH 45221 USA
[3] Shanghai Univ, Inst Biomed Engn, Shanghai 200444, Peoples R China
基金
中国国家自然科学基金;
关键词
Drug-loaded magnetic nanocomposites; graphene quantum dots; magnetic field-mediated mechanical stimulation; near-infrared laser; cancer therapy; TEMPERATURE DISTRIBUTION; PROSTATE-CANCER; IRON-OXIDE; NANOPARTICLES; THERMOTHERAPY; HYPERTHERMIA; FEASIBILITY; FABRICATION; TOXICITY; FIELDS;
D O I
10.7150/thno.13411
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
In this study, a multimodal therapeutic system was shown to be much more lethal in cancer cell killing compared to a single means of nano therapy, be it photothermal or photodynamic. Hollow magnetic nanospheres (HMNSs) were designed and synthesized for the synergistic effects of both magneto-mechanical and photothermal cancer therapy. By these combined stimuli, the cancer cells were structurally and physically destroyed with the morphological characteristics distinctively different from those by other therapeutics. HMNSs were also coated with the silica shells and conjugated with carboxylated graphene quantum dots (GQDs) as a core-shell composite: HMNS/SiO2/GQDs. The composite was further loaded with an anticancer drug doxorubicin (DOX) and stabilized with liposomes. The multimodal system was able to kill cancer cells with four different therapeutic mechanisms in a synergetic and multilateral fashion, namely, the magnetic field-mediated mechanical stimulation, photothermal damage, photodynamic toxicity, and chemotherapy. The unique nanocomposites with combined mechanical, chemo, and physical effects will provide an alternative strategy for highly improved cancer therapy efficiency.
引用
收藏
页码:485 / 500
页数:16
相关论文
共 27 条
[1]   Highly crystallized iron oxide nanoparticles as effective and biodegradable mediators for photothermal cancer therapy [J].
Chen, Hongwei ;
Burnett, Joseph ;
Zhang, Fuxiang ;
Zhang, Jiaming ;
Paholak, Hayley ;
Sun, Duxin .
JOURNAL OF MATERIALS CHEMISTRY B, 2014, 2 (07) :757-765
[2]   Morphological effect of oscillating magnetic nanoparticles in killing tumor cells [J].
Cheng, Dengfeng ;
Li, Xiao ;
Zhang, Guoxin ;
Shi, Hongcheng .
NANOSCALE RESEARCH LETTERS, 2014, 9 :1-8
[3]   The in vitro and in vivo toxicity of graphene quantum dots [J].
Chong, Yu ;
Ma, Yufei ;
Shen, He ;
Tu, Xiaolong ;
Zhou, Xuan ;
Xu, Jiaying ;
Dai, Jianwu ;
Fan, Saijun ;
Zhang, Zhijun .
BIOMATERIALS, 2014, 35 (19) :5041-5048
[4]   Near-infrared laser light mediated cancer therapy by photothermal effect of Fe3O4 magnetic nanoparticles [J].
Chu, Maoquan ;
Shao, Yuxiang ;
Peng, Jinliang ;
Dai, Xiangyun ;
Li, Haikuo ;
Wu, Qingsheng ;
Shi, Donglu .
BIOMATERIALS, 2013, 34 (16) :4078-4088
[5]   Laser light triggered-activated carbon nanosystem for cancer therapy [J].
Chu, Maoquan ;
Peng, Jinliang ;
Zhao, Jiajia ;
Liang, Shanlu ;
Shao, Yuxiang ;
Wu, Qiang .
BIOMATERIALS, 2013, 34 (07) :1820-1832
[6]   Lysosomal Membrane Permeabilization by Targeted Magnetic Nanoparticles in Alternating Magnetic Fields [J].
Domenech, Maribella ;
Marrero-Berrios, Ileana ;
Torres-Lugo, Madeline ;
Rinaldi, Carlos .
ACS NANO, 2013, 7 (06) :5091-5101
[7]   Temperature distribution for combined laser hyperthermia-photodynamic therapy in the esophagus [J].
Eichler, J ;
Liebetruth, J ;
London, RA ;
Ziegenhagen, L .
MEDICAL ENGINEERING & PHYSICS, 2000, 22 (04) :307-312
[8]   A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation [J].
Ge, Jiechao ;
Lan, Minhuan ;
Zhou, Bingjiang ;
Liu, Weimin ;
Guo, Liang ;
Wang, Hui ;
Jia, Qingyan ;
Niu, Guangle ;
Huang, Xing ;
Zhou, Hangyue ;
Meng, Xiangmin ;
Wang, Pengfei ;
Lee, Chun-Sing ;
Zhang, Wenjun ;
Han, Xiaodong .
NATURE COMMUNICATIONS, 2014, 5
[9]   The current role of photodynamic therapy in oesophageal dysplasia and cancer [J].
Gray, Joanna ;
Fullarton, Grant .
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2007, 4 (03) :151-159
[10]   Fabrication of Monodisperse Magnetite Hollow Spheres [J].
Hu, Peng ;
Yu, Lingjie ;
Zuo, Ahui ;
Guo, Chenyi ;
Yuan, Fangli .
JOURNAL OF PHYSICAL CHEMISTRY C, 2009, 113 (03) :900-906