Pharmaceutical Approaches on Antimicrobial Resistance: Prospects and Challenges

被引：30
|
作者：
Nainu, Firzan [1 ]
Permana, Andi Dian [1 ]
Djide, Nana Juniarti Natsir [1 ]
Anjani, Qonita Kurnia [1 ,2 ]
Utami, Rifka Nurul [1 ,3 ]
Rumata, Nur Rahma [1 ,4 ]
Zhang, Jianye [5 ,6 ,7 ]
Bin Emran, Talha [8 ]
Simal-Gandara, Jesus [9 ]
机构：
[1] Hasanuddin Univ, Fac Pharm, Makassar 90245, Sulawesi Selata, Indonesia
[2] Queens Univ Belfast, Med Biol Ctr, Sch Pharm, Belfast BT9 7BL, Antrim, North Ireland
[3] Kings Coll London, Inst Pharmaceut Sci, London SE1 9NH, England
[4] Sekolah Tinggi Ilmu Farmasi Makassar, Makassar 90242, Sulawesi Selata, Indonesia
[5] Guangzhou Med Univ, Key Lab Mol Target & Clin Pharmacol & State, Guangzhou 511436, Peoples R China
[6] Guangzhou Med Univ, Sch Pharmaceut Sci, NMPA Key Lab Resp Dis, Guangzhou 511436, Peoples R China
[7] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Peoples R China
[8] BGC Trust Univ Bangladesh, Dept Pharm, Chittagong 4381, Bangladesh
[9] Univ Vigo, Fac Food Sci & Technol, Dept Analyt & Food Chem, Nutr & Bromatol Grp, Ourense Campus, E-32004 Orense, Spain
来源：
ANTIBIOTICS-BASEL | 2021年 / 10卷 / 08期
关键词：
antimicrobial resistance; antimicrobials; pharmaceutical preparations; drug delivery; PULMONARY DRUG-DELIVERY; ANTIBIOTIC-RESISTANCE; SILVER NANOPARTICLES; TRANSDERMAL DELIVERY; IN-VITRO; STAPHYLOCOCCUS-AUREUS; EFFLUX PUMPS; CYCLODEXTRIN HYDROGELS; ANTIBACTERIAL ACTIVITY; SECONDARY METABOLITES;
D O I：
10.3390/antibiotics10080981
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The rapid increase in pathogenic microorganisms with antimicrobial resistant profiles has become a significant public health problem globally. The management of this issue using conventional antimicrobial preparations frequently results in an increase in pathogen resistance and a shortage of effective antimicrobials for future use against the same pathogens. In this review, we discuss the emergence of AMR and argue for the importance of addressing this issue by discovering novel synthetic or naturally occurring antibacterial compounds and providing insights into the application of various drug delivery approaches, delivered through numerous routes, in comparison with conventional delivery systems. In addition, we discuss the effectiveness of these delivery systems in different types of infectious diseases associated with antimicrobial resistance. Finally, future considerations in the development of highly effective antimicrobial delivery systems to combat antimicrobial resistance are presented.
引用
收藏
页数：33
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