Characterization of as-synthesized mesoporous silica using NMR and solid-state fluorescence spectroscopy

被引：4

作者：

Chiba, R. ^{[1
,2
]}

Kuroiwa, Y. ^{[1
]}

Higashi, K. ^{[1
]}

Yamamoto, K. ^{[1
]}

Moribe, K. ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chiba, Chiba 2608675, Japan

[2] SSP Co Ltd, Narita Res Ctr, Narita, Chiba 2868511, Japan

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2014年 / 24卷 / 06期

关键词：

Mesoporous materials; Preloading; Pluronic P123; Pyrene; Monomer emission; SBA-15; FSM-16; SIZE;

D O I：

10.1016/S1773-2247(14)50135-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study, as-synthesized mesoporous silica preloaded with pyrene was synthesized, and then its physical properties and molecular state of pyrene were evaluated. The product had mesoporous structure from small-angle X-ray scattering and scanning electron microscopy measurements. Nitrogen gas adsorption and solid-state NMR measurements confirmed that the pore spaces were filled with Pluronic P123 (P123) and pyrene. Mobility of P123 inside the pore was investigated by solid-state NMR measurement. Mobility of hydrophilic PEO chain decreased in the pore. Solid-state fluorescence measurement was used to examine the encapsulation state of pyrene. Molecular state of pyrene was compared before and after the calcination process. At a low loading amount, pyrene-loaded calcined mesoporous silica showed the superior excimer emission, whereas pyrene-loaded as-synthesized mesoporous silica gave the predominant monomer emission. The results revealed that the presence of P123 could contribute to the dispersion improvement of pyrene at the molecular level.

引用

页码：673 / 677

页数：5

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