Camphoric acid derived sulfur containing bicyclic carboxylic acids as chiral auxiliaries in N-acyliminium ion chemistry

被引：4

作者：

Braeckow, J. ^{[2
]}

Pabel, J. ^{[1
]}

Mayer, R. ^{[3
]}

Polborn, K. ^{[3
]}

Wanner, K. T. ^{[1
]}

机构：

[1] Univ Munich, Dept Pharm, Zentrum Pharmaforsch, D-81377 Munich, Germany

[2] Carbogen Amcis AG, CH-5502 Hunzenschwil, Switzerland

[3] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

TETRAHEDRON | 2010年 / 66卷 / 36期

关键词：

N-Acyliminium salt; Asymmetric synthesis; Asymmetric electrophilic alpha-amidoalkylation (AE alpha A); Thioanhydride; Thiolactone; ELECTROPHILIC ALPHA-AMIDOALKYLATION; ASYMMETRIC-SYNTHESIS; ACYLPYRIDINIUM IONS; ADDITION-REACTIONS; GENERATION; QUINOLINES; CHLORIDE;

D O I：

10.1016/j.tet.2010.07.009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three novel sulfur containing chiral bicyclic carboxylic acids were synthesized from D-camphoric acid. Two of these compounds were briefly evaluated for their potency as chiral auxiliaries in Asymmetric Electrophilic alpha-Amidoalkylation (AE alpha A) reactions. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：7279 / 7287

页数：9

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