Novel GRP78 molecular chaperone expression down-regulators JBIR-04 and -05 isolated from Streptomyces violaceoniger

被引：29
作者：
Izumikawa, Miho
Ueda, Jun-ya
Chijiwa, Shuhei
Takagi, Motoki
Shin-ya, Kazuo
机构：
[1] Natl Inst Adv Ind Sci & Technol, BIRC, Koto Ku, Tokyo 1350064, Japan
[2] JBIC, JBIRC, Koto Ku, Tokyo 1350064, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2007年 / 60卷 / 10期
关键词：
JBIR-04; and-05; streptomyces violaceoniger; neoantimycin; prunustatin a; SW-163A; molecular chaperone; GRP78;
D O I：
10.1038/ja.2007.82
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In the course of our screening program for regulators of the expression of GRP78 molecular chaperone, JBIR-04 (1) and -05 (2) were isolated from Streptomyces violaceoniger 4541-SVS3 as congeners of prunustatin A (3). The structures of 1 and 2 were determined by the analyses of the spectroscopic data. These compounds mainly consist of an amino acid and amino acid derived a-hydroxy acid residues. 1 and 2 inhibited the expression of GRP78 induced by 2-deoxyglucose in human fibrosarcoma HT1080 cells, but their activities were highly reduced compared with those of 3 and SW-163A.
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页码：640 / 644
页数：5
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