Cytotoxic isoflavans from Eysenhardtia polystachya

被引：46
作者：
Alvarez, L
Rios, MY
Esquivel, C
Chávez, MI
Delgado, G
Aguilar, MI
Villarreal, ML
Navarro, V
机构：
[1] Univ Autonoma Estado Morelos, Fac Ciencias Quim & Ingn, Dept Quim Organ, Cuernavaca 62210, Morelos, Mexico
[2] Natl Autonomous Univ Mexico, Inst Quim, Mexico City 04510, DF, Mexico
[3] Natl Autonomous Univ Mexico, Dept Farm, Mexico City 04510, DF, Mexico
[4] Unidad Invest Biomed Sur, Xochitepec, Morelos, Mexico
来源：
JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 06期
关键词：
D O I：
10.1021/np970586b
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new cytotoxic isoflavans, (3S)-7-hydroxy-2',3',4',5',8-pentamethox (1) and (3S)3',7-dihydroxy-2',4', 5', 8-tetramethoxyisoflavan (2), were isolated from the bark and trunks of Eysenhardtia polystachya (Leguminosae), together with the known constituents stigmasterol, isoduartin, cuneatin, 7-hydroxy-2',4',5'-trimethoxyisoflavone, and 3,4-dimethoxy-8,9-(methylenedioxy)pterocarpan. The structures of 1 and 2 were elucidated on the basis of spectroscopic methods. The antimicrobial, cytotoxic, and insecticidal potential of some of these compounds were evaluated. The isoflavans 1, 2, and isoduartin (2',7-dihydroxy-3',4',8-trimethoxyisoflavan) displayed moderate cytotoxic activity against KB cell lines.
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收藏
页码：767 / 770
页数：4
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