Animal models for schizophrenia

被引：0

作者：

Wolterink, G ^{[1
]}

Daenen, EWPM ^{[1
]}

Van Ree, JM ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Med Pharmacol, Rudolf Magnus Inst Neurosci, NL-3584 CG Utrecht, Netherlands

来源：

NEUROSCIENCE RESEARCH COMMUNICATIONS | 2000年 / 27卷 / 03期

关键词：

schizophrenia; neurodevelopmental disorder; animal model; amygdala lesion; hippocampus lesion; behaviour;

D O I：

10.1002/1520-6769(200011/12)27:3<143::AID-NRC1>3.0.CO;2-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Over the years a variety of animal models for schizophrenia have been developed. Initially, these models were predominantly pharmacological in nature, based on the effects of drugs used in the treatment of the disease. With increasing knowledge of the disturbances in the schizophrenic brain, and better methodologies to perform research in both patients and animals, animal models with face, predictive and construct validity have been set up. The present paper reviews a number of animal models that have been and still are used to uncover the mechanisms underlying the psychopathological processes leading to schizophrenia.

引用

页码：143 / 154

页数：12

共 68 条

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