Effects of Selective Agonists of V1a, V2, and V1b Receptors on Sodium Transport in Rat Kidney

被引：6

作者：

Golosova, D. V. ^{[1
]}

Karavashkina, T. A. ^{[1
]}

Kutina, A. V. ^{[1
]}

Marina, A. S. ^{[1
]}

Natochin, Yu. V. ^{[1
]}

机构：

[1] Russian Acad Sci, Lab Renal Physiol & Water Salt Balance, IM Sechenov Inst Evolutionary Physiol & Biochem, St Petersburg 196140, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 160卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

kidney; vasopressin receptors; sodium; reabsorption; VASOPRESSIN; WATER;

D O I：

10.1007/s10517-016-3301-x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The role of subtypes of vasopressin receptors in modulation of renal sodium reabsorption was studied in in vivo experiments on Wistar rats. Selective V-1a receptor agonist reduced sodium reabsorption in the kidneys and expression of these receptors increased by practically 100 times. This effect was similar to the effect of furosemide. Selective V-2 receptor agonist enhanced sodium reabsorption in the kidney and simultaneously increased reabsorption of solute-free water. Stimulation of V-1b receptors did not affect sodium transport. Our findings attest to the key role of V-1a receptors in the regulation of renal excretion of sodium ions.

引用

页码：751 / 754

页数：4

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