Simultaneous Determination of Seven Mental Drugs in Feeds by Liquid Chromatography-Tandem Mass Spectrometry

被引：2

作者：

Suo De-Cheng ^{[1
]}

Zhao Gen-Long ^{[1
]}

Li Lan ^{[1
]}

Su Xiao-Ou ^{[1
]}

机构：

[1] Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agr Prod, Beijing 100081, Peoples R China

来源：

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY | 2010年 / 38卷 / 07期

关键词：

Liquid chromatography-tandem mass spectrometry; Feed; Mental drug; SOLID-PHASE EXTRACTION; GAS-CHROMATOGRAPHY; HUMAN-PLASMA; MAIN METABOLITES; DIAZEPAM; URINE; LEVOMEPROMAZINE; BENZODIAZEPINES; CHLORPROMAZINE; SAMPLES;

D O I：

10.3724/SP.J.1096.2010.01023

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A method was established for the simultaneous determination of seven mental drugs by LC-MS/MS. In this method, the conditions of appropriate extracting solvent, SPE cartridge and LC-MS/MS were optimized. The drugs were extracted with acetonitrile/water (9:1, V/V), and then purified by MCX solid-phase extraction (SPE) column. The elution was evaporated by nitrogen blow, dissolved in acetonitrile/water( 2:8, V/V) and analyzed by LC-MS/MS. The limit of detection (LOD) was 1.0 ng/g of nitrazepam, oxazepam, promethazine and chlorpromazine, and 5.0 ng/g of diazepam, perphenazine; and thioridazine. The recoveries were 53.9% - 110.2%, and RSDs were 3.4% - 18.4%. Results showed that this developed method was very reliable for the determination of seven mental drugs in feeds.

引用

页码：1023 / 1026

页数：4

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