Super pH-sensitive multifunctional polymeric micelle

被引：507
|
作者：
Lee, ES [1 ]
Na, K [1 ]
Bae, YH [1 ]
机构：
[1] Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84108 USA
来源：
NANO LETTERS | 2005年 / 5卷 / 02期
关键词：
D O I：
10.1021/nl0479987
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
To endow enhanced tumor specificity and endosome disruption property on the carrier, a multifunctional polymeric micelle was investigated. The micelle exposes the cell interacting ligand (biotin) on the surface under slightly acidic environmental conditions of various solid tumors and is internalized by biotin receptor-mediated endocytosis in a short time period. The micelle also showed pH-dependent dissociation, causing the enhanced release of doxorubicin from the carrier in early endosomal pH. The dissociated micellar components subsequently disrupt endosomal membrane.
引用
收藏
页码：325 / 329
页数：5
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