1H MRS spectroscopy evidence of cerebellar high lactate in mitochondrial respiratory chain deficiency

被引：18

作者：

Boddaert, N. ^{[1
]}

Romano, S. ^{[2
,3
]}

Funalot, B. ^{[2
,3
]}

Rio, M. ^{[2
,3
]}

Sarzi, E. ^{[2
,3
]}

Lebre, A. S. ^{[2
,3
]}

Bahi-Buisson, N. ^{[2
,3
]}

Valayannopoulos, V. ^{[2
,3
]}

Desguerre, I. ^{[2
,3
]}

Seidenwurm, D. ^{[4
]}

Brunelle, F. ^{[1
]}

Brami-Zylberberg, F. ^{[5
]}

Rotig, A. ^{[2
,3
]}

Munnich, A. ^{[2
,3
]}

de Lonlay, P. ^{[3
]}

机构：

[1] Hop Necker Enfants Malad, Serv Radiol Pediat, U797, F-75015 Paris, France

[2] Hop Necker Enfants Malad, Dept Pediat, Paris, France

[3] Hop Necker Enfants Malad, INSERM, U 781, Paris, France

[4] Sutter Med Ctr, Radiol Assoc Sacromento, Sacramento, CA USA

[5] Hop St Anne, Serv Radiol, F-75674 Paris, France

来源：

MOLECULAR GENETICS AND METABOLISM | 2008年 / 93卷 / 01期

关键词：

1H MRS spectroscopy; cerebellum; mitochondrial respiratory; chain deficiency;

D O I：

10.1016/j.ymgme.2007.09.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cerebellar ataxia is known to occasionally occur in the course of mitochondrial disorders. We report on MR spectroscopy (1H MRS) evidence of elevated brain lactate in the cerebellar area of 11 patients with cerebellar ataxia ascribed to mitochondrial respiratory chain deficiency (RCD). 1H MRS spectroscopy evidence of lactate peak was found in the cerebellum of 9/11 cases, while no lactate was detected in the putamen in 8/11. We suggest using 1H MRS in cerebellar atrophy in the diagnosis of mitochondrial RCD. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：85 / 88

页数：4

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