Effects of glimepiride and glibenclamide on carotid atherosclerosis in type 2 diabetic patients

被引:7
|
作者
Katakami, Naoto [1 ]
Kaneto, Hideaki [1 ]
Matsuhisa, Munehide [2 ]
Shimomura, Iichiro [1 ]
Yamasaki, Yoshimitsu [3 ]
机构
[1] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan
[2] Univ Tokushima, Diabet Therapeut & Res Ctr, Tokushima, Japan
[3] Osaka Univ, Ctr Adv Sci & Innovat, Suita, Osaka 565, Japan
关键词
IMT; Carotid atherosclerosis; Glimepiride; Glibenclamide; INTIMA-MEDIA THICKNESS; ARTERY-DISEASE; RISK;
D O I
10.1016/j.diabres.2010.12.023
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We performed a 3-year observation study of type 2 diabetic patients treated with glibenclamide or glimepiride and found that the annual progression of the maximum carotid intima-media thickness was significantly attenuated in the subjects treated with glimepiride (n = 20) as compared with those treated with glibenclamide (n = 20) (-0.044 +/- 0.171 mm/year vs. 0.077 +/- 0.203 mm/year, p = 0.0474). (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:E20 / E22
页数:3
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