Optimal wavelength combinations for near-infrared spectroscopic monitoring of changes in brain tissue hemoglobin and cytochrome c oxidase concentrations

被引:41
作者
Arifler, Dizem [1 ]
Zhu, Tingting [2 ]
Madaan, Sara [2 ]
Tachtsidis, Ilias [2 ]
机构
[1] Middle E Tech Univ, Phys Grp, Kalkanli, Turkey
[2] UCL, Dept Med Phys & Biomed Engn, London WC1E 6BT, England
来源
BIOMEDICAL OPTICS EXPRESS | 2015年 / 6卷 / 03期
基金
英国惠康基金;
关键词
ADULT BRAIN; CROSS-TALK; OXYGEN DELIVERY; REDOX CHANGES; OPTIMIZATION; LIGHT;
D O I
10.1364/BOE.6.000933
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We analyze broadband near-infrared spectroscopic measurements obtained from newborn piglets subjected to hypoxia-ischemia and we aim to identify optimal wavelength combinations for monitoring cerebral tissue chromophores. We implement an optimization routine based on the genetic algorithm to perform a heuristic search for discrete wavelength combinations that can provide accurate concentration information when benchmarked against the gold standard of 121 wavelengths. The results indicate that it is possible to significantly reduce the number of measurement wavelengths used in conjunction with spectroscopic algorithms and still achieve a high performance in estimating changes in concentrations of oxyhemoglobin, deoxyhemoglobin, and oxidized cytochrome c oxidase. While the use of a 3-wavelength combination leads to mean recovery errors of up to 10%, these errors drop to less than 4% with 4 or 5 wavelengths and to even less than 2% with 8 wavelengths. (C) 2015 Optical Society of America
引用
收藏
页码:933 / 947
页数:15
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