Guardians of the barrier: Microbiota engage AHR in keratinocytes to mantain skin homeostasis

被引：7

作者：

Alwan, Wisam ^{[1
,2
]}

Di Meglio, Paola ^{[2
]}

机构：

[1] Guys & St Thomas NHS Fdn Trust, London, England

[2] Kings Coll London, Sch Basic & Med Biosci, St Johns Inst Dermatol, London, England

来源：

CELL HOST & MICROBE | 2021年 / 29卷 / 08期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.chom.2021.07.007

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The skin barrier is critical in ensuring homeostasis, yet factors influencing its development, repair, and maintenance are ill-defined. In this issue of Cell Host & Microbe, Uberoi et al. demonstrate the skin microbiota's role in maintaining barrier integrity via AHR signaling in keratinocytes, which has implications for skin disease management.

引用

页码：1213 / 1216

页数：5

共 10 条

[1] Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions [J].

Di Meglio, Paola ;

Duarte, Joao H. ;

Ahlfors, Helena ;

Owens, Nick D. L. ;

Li, Ying ;

Villanova, Federica ;

Tosi, Isabella ;

Hirota, Keiji ;

Nestle, Frank O. ;

Mrowietz, Ulrich ;

Gilchrist, Michael J. ;

Stockinger, Brigitta .

IMMUNITY, 2014, 40 (06) :989-1001

[2] Microbe-host interplay in atopic dermatitis and psoriasis [J].

Fyhrquist, Nanna ;

Muirhead, Gareth ;

Prast-Nielsen, Stefanie ;

Jeanmougin, Marine ;

Olah, Peter ;

Skoog, Tiina ;

Jules-Clement, Gerome ;

Feld, Micha ;

Barrientos-Somarribas, Mauricio ;

Sinkko, Hanna ;

van den Bogaard, Ellen H. ;

Zeeuwen, Patrick L. J. M. ;

Rikken, Gijs ;

Schalkwijk, Joost ;

Niehues, Hanna ;

Daeubener, Walter ;

Eller, Silvia Kathrin ;

Alexander, Helen ;

Pennino, Davide ;

Suomela, Sari ;

Tessas, Ioannis ;

Lybeck, Emilia ;

Baran, Anna M. ;

Darban, Hamid ;

Gangwar, Roopesh Singh ;

Gerstel, Ulrich ;

Jahn, Katharina ;

Karisola, Piia ;

Yan, Lee ;

Hansmann, Britta ;

Katayama, Shintaro ;

Meller, Stephan ;

Bylesjo, Max ;

Hupe, Philippe ;

Levi-Schaffer, Francesca ;

Greco, Dario ;

Ranki, Annamari ;

Schroeder, Jens M. ;

Barker, Jonathan ;

Kere, Juha ;

Tsoka, Sophia ;

Lauerma, Antti ;

Soumelis, Vassili ;

Nestle, Frank O. ;

Homeyl, Bernhard ;

Andersson, Bjorn ;

Alenius, Harri .

NATURE COMMUNICATIONS, 2019, 10 (1)

[3] A phase 2b, randomized clinical trial of tapinarof cream for the treatment of plaque psoriasis: Secondary efficacy and patient-reported outcomes [J].

Gold, Linda Stein ;

Bhatia, Neal ;

Tallman, Anna M. ;

Rubenstein, David S. .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2021, 84 (03) :624-631

[4] CYP1A1 Enzymatic Activity Influences Skin Inflammation Via Regulation of the AHR Pathway [J].

Kyoreva, Mariela ;

Li, Ying ;

Hoosenally, Mariyah ;

Hardman-Smart, Jonathan ;

Morrison, Kirsten ;

Tosi, Isabella ;

Tolaini, Mauro ;

Barinaga, Guillermo ;

Stockinger, Brigitta ;

Mrowietz, Ulrich ;

Nestle, Frank O. ;

Smith, Catherine H. ;

Barker, Jonathan N. ;

Di Meglio, Paola .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2021, 141 (06) :1553-+

[5] The global burden of atopic dermatitis: lessons from the Global Burden of Disease Study 1990-2017 [J].

Laughter, M. R. ;

Maymone, M. B. C. ;

Mashayekhi, S. ;

Arents, B. W. M. ;

Karimkhani, C. ;

Langan, S. M. ;

Dellavalle, R. P. ;

Flohr, C. .

BRITISH JOURNAL OF DERMATOLOGY, 2021, 184 (02) :304-309

[6] Efficacy and patient-reported outcomes from a phase 2b, randomized clinical trial of tapinarof cream for the treatment of adolescents and adults with atopic dermatitis [J].

Paller, Amy S. ;

Gold, Linda Stein ;

Soung, Jennifer ;

Tallman, Anna M. ;

Rubenstein, David S. ;

Gooderham, Melinda .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2021, 84 (03) :632-638

[7] Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema [J].

Sandilands, Aileen ;

Terron-Kwiatkowski, Ana ;

Hull, Peter R. ;

O'Regan, Grainne M. ;

Clayton, Timothy H. ;

Watson, Rosemarie M. ;

Carrick, Thomas ;

Evans, Alan T. ;

Liao, Haihui ;

Zhao, Yiwei ;

Campbell, Linda E. ;

Schmuth, Matthias ;

Gruber, Robert ;

Janecke, Andreas R. ;

Elias, Peter M. ;

van Steensel, Maurice A. M. ;

Nagtzaam, Ivo ;

van Geel, Michel ;

Steijlen, Peter M. ;

Munro, Colin S. ;

Bradley, Daniel G. ;

Palmer, Colin N. A. ;

Smith, Frances J. D. ;

McLean, W. H. Irwin ;

Irvine, Alan D. .

NATURE GENETICS, 2007, 39 (05) :650-654

[8] Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor [J].

Uberoi, Aayushi ;

Bartow-McKenney, Casey ;

Zheng, Qi ;

Flowers, Laurice ;

Campbell, Amy ;

Knight, Simon A. B. ;

Chan, Neal ;

Wei, Monica ;

Lovins, Victoria ;

Bugayev, Julia ;

Horwinski, Joseph ;

Bradley, Charles ;

Meyer, Jason ;

Crumrine, Debra ;

Sutter, Carrie Hayes ;

Elias, Peter ;

Mauldin, Elizabeth ;

Sutter, Thomas R. ;

Grice, Elizabeth A. .

CELL HOST & MICROBE, 2021, 29 (08) :1235-+

[9] Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis [J].

van den Bogaard, Ellen H. ;

Bergboer, Judith G. M. ;

Vonk-Bergers, Mieke ;

van Vlijmen-Willems, Ivonne M. J. J. ;

Hato, Stanleyson V. ;

van der Valk, Pieter G. M. ;

Schroeder, Jens Michael ;

Joosten, Irma ;

Zeeuwen, Patrick L. J. M. ;

Schalkwijk, Joost .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (02) :917-927

[10] A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor [J].

Yu, Jinlei ;

Luo, Yang ;

Zhu, Zhenlai ;

Zhou, Yufeng ;

Sun, Licheng ;

Gao, Jixin ;

Sun, Jinlv ;

Wang, Gang ;

Yao, Xu ;

Li, Wei .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019, 143 (06) :2108-+

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