Convenient divergent strategy for the synthesis of TunePhos-type chiral diphosphine ligands and their applications in highly enantioselective Ru-catalyzed hydrogenations

被引：69
作者：
Sun, Xianfeng [1 ]
Zhou, Le [2 ]
Li, Wei [1 ]
Zhang, Xumu [1 ]
机构：
[1] Rutgers State Univ, Dept Chem & Chem Biol & Pharmaceut Chem, Piscataway, NJ 08854 USA
[2] NW A&F Univ, Coll Sci, Yangling 712100, Shaanxi, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 03期
关键词：
D O I：
10.1021/jo702068w
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] A convenient, divergent strategy for the synthesis of a series of modular and fine-tunable C-3-TunePhos-type chiral diphosphine ligands and their applications in highly efficient Ru-catalyzed asymmetric hydrogenations were explored. Up to 97 and 99% ee values were achieved for the enantio selective synthesis of beta-methyl chiral amines and alpha-hydroxy acid derivatives, respectively.
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页码：1143 / 1146
页数：4
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