A New and Improved Synthesis of the Precursor of the Hypoxia Marker [18F]-FMISO

被引：5

作者：

Nieto, Elena ^{[1
]}

Alajarin, Ramon ^{[1
]}

Alvarez-Builla, Julio ^{[1
]}

Larranaga, Ignacio ^{[2
]}

Gorospe, Elena ^{[2
]}

Pozo, Miguel A. ^{[3
]}

机构：

[1] Univ Alcala, Dept Quim Organ, Fac Farm, Madrid 28871, Spain

[2] Inst Tecnol PET, Madrid 28040, Spain

[3] Univ Complutense Madrid, Inst Pluridisciplinar, E-28040 Madrid, Spain

来源：

SYNTHESIS-STUTTGART | 2010年 / 21期

关键词：

F-18]-FMISO; hypoxia; radiopharmaceutical; regioselective tosylation; FLUOROMISONIDAZOLE; RADIOSYNTHESIS;

D O I：

10.1055/s-0030-1258269

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthetic approach to the precursor of the hypoxia marker [F-18]-FMISO has been developed. Three different tosylation methods were studied for the preparation of the key intermediate. The overall yield is markedly higher than the yields reported for previous syntheses. The precursor was used to prepare [F-18]-FMISO and the results were comparable to those obtained when a commercial precursor was used.

引用

页码：3700 / 3704

页数：5

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