THE POTENTIAL OF CD4+ REGULATORY T CELLS FOR THE THERAPY OF AUTOIMMUNE DISEASES

被引：1

作者：

Churov, A., V ^{[1
]}

Siutkina, A., I ^{[2
]}

Mamashov, K. Y. ^{[3
]}

Oleinik, E. K. ^{[1
]}

机构：

[1] Russian Acad Sci, Karelian Res Ctr, Petrozavodsk, Russia

[2] Perm State Pharmaceut Acad, Perm, Russia

[3] Kemerovo State Med Univ, Kemerovo, Russia

来源：

BULLETIN OF RUSSIAN STATE MEDICAL UNIVERSITY | 2019年 / 06期

关键词：

regulatory T cells; FOXP3; autoimmune disease; immunotherapy; cell therapy; CAR-Treg therapy; CRISPR/Cas9;

D O I：

10.24075/brsmu.2019.082

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Despite the considerable progress in the therapy of autoimmune pathologies, the existing methods are associated with the risk of serious adverse events. We think that regulatory T cells hold great promise for the therapy of disorders caused by a breakdown in immunological self-tolerance. This article aims at estimating the possible challenges facing Treg-based clinical approaches and offers solutions to the technical issues associated with the use of these cells in the therapy of autoimmune diseases.

引用

页码：71 / 75

页数：5

共 50 条

[1] Epigenetics of CD4+ T cells in autoimmune diseases
Wang, Zijun
Chang, Christopher
Lu, Qianjin
CURRENT OPINION IN RHEUMATOLOGY, 2017, 29 (04) : 361 - 368
[2] CD4+ T-regulatory cells:: toward therapy for human diseases
Allan, Sarah E.
Broady, Raewyn
Gregori, Silvia
Himmel, Megan E.
Locke, Natasha
Roncarolo, Maria Grazia
Bacchetta, Rosa
Levings, Megan K.
IMMUNOLOGICAL REVIEWS, 2008, 223 : 391 - 421
[3] CD4+ CD25+ FoxP3+ regulatory T cells in autoimmune diseases
Valencia, Xavier
Lipsky, Peter E.
NATURE CLINICAL PRACTICE RHEUMATOLOGY, 2007, 3 (11): : 619 - 626
[4] Regulatory CD4+ T cells and the control of autoimmune disease
Wraith, DC
Nicolson, KS
Whitley, NT
CURRENT OPINION IN IMMUNOLOGY, 2004, 16 (06) : 695 - 701
[5] Therapeutic potential of TGF-β-induced CD4+ Foxp3+ regulatory T cells in autoimmune diseases
Zhou, Xiaohui
Kong, Ning
Zou, Hejian
Brand, David
Li, Xianpei
Liu, Zhongmin
Zheng, Song Guo
AUTOIMMUNITY, 2011, 44 (01) : 43 - 50
[6] Memory CD4+ T Cells in Immunity and Autoimmune Diseases
Raphael, Itay
Joern, Rachel R.
Forsthuber, Thomas G.
CELLS, 2020, 9 (03)
[7] Understanding CD4+ T cells in autoimmune bullous diseases
Lee, A. Yeong
Kim, Taehee
Kim, Jong Hoon
FRONTIERS IN IMMUNOLOGY, 2023, 14
[8] Diversity of regulatory CD4+ T cells controlling distinct organ-specific autoimmune diseases
Alyanakian, MA
You, S
Damotte, D
Gouarin, C
Esling, A
Garcia, C
Havouis, S
Chatenoud, L
Bach, JF
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (26) : 15806 - 15811
[9] CD4+CD25+T regulatory cells in autoimmune diseases
Valencia, X
He, LS
Illei, G
Lipsky, PE
FASEB JOURNAL, 2004, 18 (05): : A832 - A832
[10] Unique CD4+ T cells characterize several autoimmune diseases
不详
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2020, 140 (03) : 506 - 506

← 1 2 3 4 5 →