THE POTENTIAL OF CD4+ REGULATORY T CELLS FOR THE THERAPY OF AUTOIMMUNE DISEASES

被引：1

作者：

Churov, A., V ^{[1
]}

Siutkina, A., I ^{[2
]}

Mamashov, K. Y. ^{[3
]}

Oleinik, E. K. ^{[1
]}

机构：

[1] Russian Acad Sci, Karelian Res Ctr, Petrozavodsk, Russia

[2] Perm State Pharmaceut Acad, Perm, Russia

[3] Kemerovo State Med Univ, Kemerovo, Russia

来源：

BULLETIN OF RUSSIAN STATE MEDICAL UNIVERSITY | 2019年 / 06期

关键词：

regulatory T cells; FOXP3; autoimmune disease; immunotherapy; cell therapy; CAR-Treg therapy; CRISPR/Cas9;

D O I：

10.24075/brsmu.2019.082

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Despite the considerable progress in the therapy of autoimmune pathologies, the existing methods are associated with the risk of serious adverse events. We think that regulatory T cells hold great promise for the therapy of disorders caused by a breakdown in immunological self-tolerance. This article aims at estimating the possible challenges facing Treg-based clinical approaches and offers solutions to the technical issues associated with the use of these cells in the therapy of autoimmune diseases.

引用

页码：71 / 75

页数：5

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