Remote meta-C-H Olefination of Phenylacetic Acids Directed by a Versatile U-Shaped Template

被引：118

作者：

Deng, Youqian ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 03期

关键词：

C-H activation; olefination; palladium; phenylacetic acid; template synthesis; ELECTRON-DEFICIENT ARENES; OXIDATIVE ALKENYLATION; BOND ACTIVATION; ARYLATION; FUNCTIONALIZATION; SELECTIVITY; ALKYLATION; REACTIVITY; PYRIDINES; CATALYSTS;

D O I：

10.1002/anie.201409860

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

meta-C-H olefination of phenylacetic acid derivatives has been achieved using a commercially available nitrile-containing template. The identification of N-formyl-protected glycine as the ligand (Formyl-Gly-OH) was crucial for the development of this reaction. Versatility of the template approach in accommodating macrocyclopalladation processes with different ring sizes is demonstrated.

引用

页码：888 / 891

页数：4

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