Self-assembly of cyclodextrins: formation of cyclodextrin polymer based nanoparticles

被引：1

作者：

Fulop, Z. ^{[1
]}

Kurkov, S. V. ^{[1
]}

Nielsen, T. T. ^{[2
]}

Larsen, K. L. ^{[2
]}

Loftsson, T. ^{[1
]}

机构：

[1] Univ Iceland, Fac Pharmaceut Sci, IS-107 Reykjavik, Iceland

[2] Aalborg Univ, Sect Chem, Dept Biotechnol Chem & Environm Engn, DK-9000 Aalborg, Denmark

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2012年 / 22卷 / 03期

关键词：

Cyclodextrins; Cyclodextrin polymers; Self-assembly; Aggregation; Nanoparticles; Stabilization; VISCOSITY B-COEFFICIENTS; APPARENT MOLAR VOLUMES; BETA-CYCLODEXTRIN; DRUG-DELIVERY; GAMMA-CYCLODEXTRIN; AQUEOUS-SOLUTIONS; PHARMACEUTICAL APPLICATIONS; INCLUSION COMPLEXES; AGGREGATION; NANOASSEMBLIES;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The design of functional cyclodextrin (CD) nanoparticles is a developing area in the field of nanomedicine. CDs can not only help in the formation of drug carriers but also increase the local concentration of drugs at the site of action. CD monomers form aggregates by self-assembly, a tendency that increases upon formation of inclusion complexes with lipophilic drugs. However, the stability of such aggregates is not sufficient for parenteral administration. In this review CD polymers and CD containing nanoparticles are categorized, with focus on self-assembled CD nanoparticles. It is described how the nanoparticles can be stabilized and tuned to have specific properties.

引用

页码：215 / 221

页数：7

共 71 条

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